物理刺激对骨损伤修复中间充质干细胞功能影响的研究进展  

Research advances in effect of physical stimulation on function of mesenchymal stem cells during bone injury repair

作　　者：刘留 江小霞 赵千 张兵 徐璐璐[2] LIU Liu;JIANG Xiaoxia;ZHAO Qian;ZHANG Bing;XU Lulu(Chinese PLA Medical School,Beijing 100853,China;Department of Orthodontics,the First Medical Center,Chinese PLA General Hospital,Beijing 100853,China;Institute of Military Cognition and Brain Science,Academy of Military Sciences,Beijing 100039,China)

机构地区：[1]解放军医学院,北京100853 [2]解放军总医院第一医学中心口腔正畸科,北京100853 [3]军事科学院军事医学研究院军事认知与脑科学研究所,北京100039

出　　处：《解放军医学院学报》2024年第7期794-798,804,共6页Academic Journal of Chinese PLA Medical School

基　　金：国家自然科学基金项目(82170986)。

摘　　要：外伤、发育畸形、炎症或肿瘤等均可能导致骨损伤,在影响人体健康的同时带来一定经济负担。骨损伤治疗是一个长期的修复过程,间充质干细胞在这个过程中发挥着至关重要的作用,其主要功能包括组织修复再生、造血支持和免疫调节等。物理刺激是一种在骨科实践中用于增强组织修复能力和合成代谢活性的非侵入性治疗,对间充质干细胞的功能具有一定影响,有效使用可以很好地促进骨损伤修复,帮助患者早日康复。本文旨在通过综述磁场、电场、超声波和光等物理刺激对骨损伤修复中间充质干细胞功能的影响及相关机制研究,为临床中使用物理刺激进行骨损伤治疗和改善预后提供参考。Diseases such as trauma,developmental malformation,inflammation or tumor may lead to bone injury,which not only affects human health but also brings a certain degree of economic burden.The treatment of bone injury is a long-term repair process,and mesenchymal stem cells play a crucial role in this process.Their main biological effects include tissue repair and regeneration,hematopoietic support and immune regulation.Physical stimulation is a non-invasive treatment used in orthopedic practice to enhance tissue repair and anabolic activity,which has a certain effect on the function of bone injury mesenchymal stem cells.Effective use of it can promote bone injury repair well and help patients recover early.This article focuses on the effects of physical stimulation such as magnetic field,electric field,ultrasound and light on the function of mesenchymal stem cells in bone injury repair and the related mechanisms,so as to provide a useful reference for the clinical use of physical stimulation in the treatment of bone injury and improve the prognosis.

关 键 词：物理刺激 间充质干细胞 磁场疗法 电场疗法 超声波疗法 光疗法 

分 类 号：R782.4[医药卫生—口腔医学]