近红外荧光引导手术在口腔癌治疗中的应用及展望  

Application and prospects of near-infrared fluorescence guided surgery in the treatment of oral cancer

作　　者：谢狄亚 肖涛 单丹妮 周婷[1] 王志勇[1] XIE Diya;XIAO Tao;SHAN Danni;ZHOU Ting;WANG Zhiyong(Department of Oral and Maxillofacial Surgery,Nanjing Stomatological Hospital,Affiliated Hospital of Medical School,Institute of Stomatology,Nanjing University,Nanjing 210008,China)

机构地区：[1]南京大学医学院附属口腔医院,南京市口腔医院口腔颌面外科,南京大学口腔医学研究所,南京210008

出　　处：《口腔颌面外科杂志》2024年第4期251-258,共8页Journal of Oral and Maxillofacial Surgery

基　　金：江苏省重点研发计划(BE2018618)。

摘　　要：口腔癌原发灶的完整切除及颈部转移淋巴结的彻底清扫,是口腔癌手术治疗成功的关键。然而,在手术过程中,除了依赖冰冻活检技术外,手术医生尚无便捷、有效的辅助手段评估肿瘤根治的彻底性。近年来,以近红外荧光(near-infrared fluorescence,NIF)成像技术为基础的荧光引导手术(fluorescence-guided surgery,FGS)逐渐成熟,为医生提供了重要的术中实时辅助,得到广泛认可和应用,而其在口腔癌外科治疗中的应用尚处于起步阶段。本文介绍该技术在口腔癌手术中的具体临床应用场景,讨论目前尚存的挑战并展望未来的发展方向,以期为临床应用和研究提供参考。The complete resection of tumor and metastatic cervical lymph nodes are the key to the successful surgical treatment of oral cancer.However,during the operation,surgeons do not have a convenient and effective auxiliary means to evaluate the completeness of tumor eradication,in addition to relying on frozen biopsy techniques.In recent years,with the development of near-infrared fluorescence(NIF)imaging,fluorescence-guided surgery(FGS)has gradually evolved,providing important real-time intraoperative assistance for surgeons,and has also been widely recognized and applied in clinical practice.The application of fluorescence imaging in the surgical treatment of oral squamous cell carcinoma(OSCC)is still in its early stages.This article introduces the specific clinical application scenarios of this technology in oral cancer surgery,discusses the current challenges,and looks forward to future development,so as to provide reference for its clinical application and research.

关 键 词：口腔鳞状细胞癌 吲哚菁绿 近红外荧光成像 荧光引导手术 

分 类 号：R782[医药卫生—口腔医学]