BATF2在胃癌组织中的表达及与患者临床病理特征和预后的关系  

The expression of BATF2 in gastric cancer tissue and its relationship with clinical pathological characteristics and prognosis of patients

作　　者：郭明海 刘记恩[1] 刘小慧 张云杰[1] 王伟栋 李明辉[1] GUO Minghai;LIU Jien;LIU Xiaohui;ZHANG Yunjie;WANG Weidong;LI Minghui(Department 8 of General Surgery,Handan Central Hospital,Handan 056002,China;Department 2 of General Surgery,Handan Central Hospital,Handan 056002,China)

机构地区：[1]邯郸市中心医院普外八科,河北邯郸056002 [2]邯郸市中心医院普外二科,河北邯郸056002

出　　处：《胃肠病学和肝病学杂志》2024年第8期982-986,共5页Chinese Journal of Gastroenterology and Hepatology

基　　金：河北省重点研发计划健康医疗与生物医药专项项目(172777201)。

摘　　要：目的 探讨碱性亮氨酸拉链转录因子2(basic leucine zipper ATF-like transcription factor 2,BATF2)在胃癌组织中的表达及与患者临床病理特征和预后的关系。方法 收集我院2016年6月至2017年11月134例胃癌患者手术切除的胃癌组织及癌旁组织标本,采用qRT-PCR法测定BATF2的mRNA表达,免疫组化法检测BATF2蛋白表达。分析胃癌患者BATF2表达与临床病理特征间的关系。采用Cox回归分析胃癌患者预后影响因素,Kaplan-Meier法分析BATF2表达与患者预后的关系。结果 胃癌组织中BATF2 mRNA和蛋白表达均显著低于癌旁组织(P<0.05),淋巴结转移、TNM分期为Ⅲ+Ⅳ期、细胞浸润程度为T_(3)~T_(4)、细胞分化程度为低分化的胃癌患者BATF2蛋白阳性表达比例显著低于淋巴结未转移、TNM分期为Ⅰ+Ⅱ期、细胞浸润程度为T_(0)~T_(2)、细胞分化程度为中/高分化的患者(P<0.05)。多因素Cox分析结果表明,淋巴结转移、TNM分期、细胞分化程度、BATF2是胃癌患者预后、复发或死亡的影响因素(P<0.05);Kaplan-Meier法分析结果表明,胃癌患者5年内预后良好率为74.63%(100/134),BATF2高表达患者5年预后良好率(93.33%)显著高于BATF2低表达患者(69.23%)(χ~2=6.445,P<0.05)。结论 BATF2表达与胃癌患者临床病理特征具有密切关系,是胃癌患者复发或死亡的影响因素,BATF2表达上调可能提高胃癌患者生存率。Objective To investigate the expression of basic leucine zipper ATF-like transcription factor 2(BATF2)in gastric cancer and its relationship with clinicopathological characteristics and prognosis.Methods Gastric cancer tissue and adjacent tissue samples were collected from 134 gastric cancer patients who underwent surgical resection in our hospital from Jun.2016 to Nov.2017.The mRNA expression of BATF2 was determined by qRT-PCR,and immunohistochemical method was applied to detect the protein expression of BATF2.Clinical pathological characteristics such as tumor diameter,degree of cell infiltration,TNM staging and lymph node metastasis were collected from patients,and the relationship between BATF2 expression and clinical pathological features in gastric cancer patients was analyzed.Multivariate Cox regression was applied to analyze the influencing factors of prognosis in gastric cancer patients.Kaplan-Meier method was applied to analyze the relationship between BATF2 expression in gastric cancer tissue and prognosis.Results The expression of BATF2 mRNA and protein in gastric cancer tissues was significantly lower than that in adjacent tissues(P<0.05),the positive expression rate of BATF2 protein in gastric cancer patients with lymph node metastasis,TNM stageⅢ+Ⅳ,cell infiltration degree T_(3)-T_(4),and low differentiation degree was obviously lower than that in patients with non-lymph node metastasis,TNM stageⅠ+Ⅱ,cell infiltration degree T_(0)-T_(2),and medium/high cell differentiation degree(P<0.05).The results of multivariate Cox analysis showed that lymph node metastasis,TNM staging,degree of cell differentiation and BATF2 were the influencing factors for the prognosis,recurrence,or death of gastric cancer patients(P<0.05);Kaplan-Meier method analysis showed that the good prognosis rate of gastric cancer patients within 5 years was 74.63%(100/134),the 5-year good prognosis rate(93.33%)of patients with high expression of BATF2 was obviously higher than that of patients with low expression of BATF2(69.23

关 键 词：碱性亮氨酸拉链转录因子2 胃癌 临床病理特征 预后 

分 类 号：R735.2[医药卫生—肿瘤]