慢性丙型病毒性肝炎患者血清IL-26、25(OH)D水平变化及其临床意义  

Changes of serum IL-26 and 25 ( OH ) D levels in patients with chronic hepatitis C and its clinical significance

作　　者：赵琳[1] 杨斌[2] 赵锁 王科文 ZHAO Lin;YANG Bin;ZHAO Suo;WANG Kewen(Department of Infection,No.987 Hospital of Joint Logistics Support Force of Chinese People′s Liberation Army,Baoji 721000;Department of Pharmacy and Laboratory Medicine,the Third Military Medical University;Department of Tuberculosis,No.987 Hospital of Joint Logistics Support Force of Chinese People′s Liberation Army,China)

机构地区：[1]中国人民解放军联勤保障部队第九八七医院感染科,陕西宝鸡721000 [2]第三军医大学药学与检验医学系药剂科 [3]中国人民解放军联勤保障部队第九八七医院结核科

出　　处：《胃肠病学和肝病学杂志》2024年第8期1010-1014,共5页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的 探讨慢性丙型病毒性肝炎(chronic hepatitis C, CHC)患者血清IL-26、25(OH)D水平变化及其临床意义。方法 选取2022年1月至2023年1月中国人民解放军联勤保障部队第九八七医院收治的120例CHC患者作为研究组,选取我院同期健康体检者50名作为对照组,采用ELISA检测IL-26及25(OH)D水平。结果 与对照组相比,研究组患者血清中IL-26水平升高,25(OH)D水平降低(P<0.05);与F_(0)~F_(1)分级相比,F_(2)~F_(3)分级的CHC患者血清中IL-26升高,25(OH)D水平降低(P<0.05);与F_(2)~F_(3)分级相比,F_(4)分级的CHC患者血清中IL-26升高,25(OH)D水平降低(P<0.05);与高病毒载量组相比,低病毒载量组的CHC患者血清中IL-26降低,25(OH)D水平升高(P<0.05);治疗后,CHC患者血清中IL-26水平降低,25(OH)D升高(P<0.05);与不良预后患者的CHC患者相比,非不良预后的CHC患者血清中IL-26水平降低,25(OH)D水平升高(P<0.05);在CHC患者中IL-26、25(OH)D呈负相关(r=-0.766,P<0.001)。结论 CHC患者血清IL-26升高、25(OH)D降低,并与肝纤维化程度及HCV病毒载量有关。临床治疗后,可逆转这一现象。Objective To investigate the changes of serum IL-26,25(OH)D levels in patients with chronic hepatitis C(CHC)and its clinical significance.Methods A total of 120 patients with CHC admitted to our hospital from Jan.2022 to Jan.2023 were selected as the study group,and 50 healthy subjects in No.987 Hospital of Joint Logistics Support Force of Chinese People′s Liberation Army at the same time were selected as the control group.Results Compared with the control group,the levels of IL-26 and 25(OH)D were increased in the study group(P<0.05).Compared with F_(0)-F_(1),serum IL-26 and 25(OH)D levels in CHC patients with F_(2)-F_(3) classification were increased and decreased,with statistical significance(P<0.05).Compared with F_(2)-F_(3),serum IL-26 and 25(OH)D levels in CHC patients with F_(4) classification were increased(P<0.05).Compared with the high viral load group,the serum IL-26 and 25(OH)D levels of CHC patients in the low viral load group were decreased(P<0.05).After treatment,IL-26 levels were decreased while 25(OH)D levels were increased in CHC patients,respectively(P<0.05).Compared with CHC patients with poor prognosis,serum IL-26 level was decreased and 25(OH)D level was increased in CHC patients with non-poor prognosis,and the difference was statistically significant(P<0.05).IL-26 and 25(OH)D were negatively correlated in patients with CHC(r=-0.766,P<0.001).Conclusion Serum IL-26 and 25(OH)D levels in patients with chronic C viral hepatitis are elevated and correlated with the degree of liver fibrosis and HCV viral load.Post-clinical treatment,this phenomenon can be reversed.

关 键 词：慢性丙型病毒性肝炎 白细胞介素26 25羟维生素D 病毒载量 肝纤维化 

分 类 号：R575.1[医药卫生—消化系统]