结直肠癌并发肌少症的临床特征及危险因素分析  

Analysis of clinical characteristics and risk factors of colorectal cancer complicated with sarcopenia

作　　者：王燕燕[1,2] 李琼 安慧颖[1] 陈艳 刘博伟[1] WANG Yanyan;LI Qiong;AN Huiying;CHEN Yan;LIU Bowei(Gastroenterology Department,Henan Provincial People's Hospital,Zhengzhou 450000;School of Nursing,Xinxiang Medical University,Xinxiang 453003,China)

机构地区：[1]河南省人民医院消化内科,河南郑州450000 [2]新乡医学院护理学院,河南新乡453003

出　　处：《临床医学研究与实践》2024年第24期1-4,共4页Clinical Research and Practice

基　　金：河南省医学科技攻关计划项目(No.SBGJ202102042)。

摘　　要：目的探索结直肠癌并发肌少症的临床特征及危险因素。方法选取2022年4月至9月收治的341例结直肠癌患者为研究对象,根据是否合并肌少症将其分为合并组(合并肌少症)和未合并组(未合并肌少症)。比较两组的一般资料及临床特征;采用二元Logistic回归分析探究影响结直肠癌患者合并肌少症的因素。结果341例结直肠癌患者中,合并肌少症104例,占比30.50%;未合并肌少症237例,占比69.50%。两组的年龄、原发肿瘤部位、体质量指数(BMI)、合并肺转移比较,差异具有统计学意义(P<0.05)。两组的临床症状、浸润深度比较,差异具有统计学意义(P<0.05);两组的分化程度、Dukes分期无明显差异(P>0.05)。年龄≥60岁、原发肿瘤位于直肠、高水平BMI、合并肺转移、浸润深度T_(3)~T_(4)期是导致结直肠癌患者合并肌少症的独立危险因素(P<0.05)。结论年龄、原发肿瘤部位、BMI、肺转移、浸润深度是导致结直肠癌患者合并肌少症的危险因素,需警惕此类危险因子,从而减少或预防肌少症的发生。Objective To explore the clinical characteristics and risk factors of colorectal cancer complicated with sarcopenia.Methods A total of 341 patients with colorectal cancer admitted from April to September 2022 were selected as the research objects.According to whether combined with sarcopenia,the patients were divided into combined group(combined with sarcopenia)and non-combined group(non-combined with sarcopenia).The general data and clinical characteristics of the two groups were compared;binary Logistic regression analysis was used to explore the factors affecting sarcopenia in patients with colorectal cancer.Results Among the 341 patients with colorectal cancer,there were 104 cases of sarcopenia,accounting for 30.50%;there were 237 cases without sarcopenia,accounting for 69.50%.There were statistically significant differences in age,primary tumor location,body mass index(BMI)and lung metastasis between the two groups(P<0.05).There were statistically significant differences in clinical symptoms and invasion depth between the two groups(P<0.05);there were no significant differences in the degree of differentiation and Dukes stage between the two groups(P>0.05).Age≥60 years old,primary tumor located in the rectum,high level of BMI,combined with lung metastasis,and invasion depth with T_(3)-T_(4) stage were independent risk factors for colorectal cancer patients complicated with sarcopenia(P<0.05).Conclusion Age,primary tumor location,BMI,lung metastasis,and invasion depth are risk factors for sarcopenia in patients with colorectal cancer,it is necessary to be alert to such risk factors to reduce or prevent the occurrence of sarcopenia.

关 键 词：结直肠癌 肌少症 临床特征 危险因素 二元Logistic回归分析 

分 类 号：R735.34[医药卫生—肿瘤]