亚低温治疗联合小骨窗颅内血肿清除术对高血压脑出血重症患者神经细胞因子及血管活性因子的影响  

Effects of mild hypothermia therapy combined with small bone window intracranial hematoma removal on neuronal cytokines and vasoactive factors in patients with severe hypertensive cerebral hemorrhage

作　　者：郭延莉 左娜 田永娟 GUO Yanli;ZUO Na;TIAN Yongjuan(Neurosurgery Department,Nanyang Central Hospital,Nanyang 473000,China)

机构地区：[1]南阳市中心医院神经外科,河南南阳473000

出　　处：《临床医学研究与实践》2024年第24期82-85,共4页Clinical Research and Practice

摘　　要：目的研究亚低温治疗联合小骨窗颅内血肿清除术对高血压脑出血重症患者神经细胞因子及血管活性因子的影响。方法选取2020年1月至2023年1月我院收治的62例高血压脑出血重症患者,根据治疗方案不同将其分为对照组和观察组,各31例。对照组采用小骨窗颅内血肿清除术治疗,观察组在对照组基础上联合亚低温治疗。比较两组的治疗效果。结果观察组的治疗总有效率高于对照组(P<0.05)。治疗后,观察组的脑血肿体积小于对照组,颅内压低于对照组(P<0.05)。治疗后,观察组的神经元特异性烯醇化酶(NSE)、神经肽Y(NPY)、内皮素(ET)及血管升压素(AVP)水平低于对照组(P<0.05)。治疗后,观察组的美国国立卫生研究院卒中量表(NIHSS)评分低于对照组,格拉斯哥昏迷量表(GCS)评分高于对照组(P<0.05)。结论亚低温联合小骨窗颅内血肿清除术能有效缩小高血压脑出血重症患者的脑血肿体积,降低颅内压及神经细胞因子、血管活性因子水平,改善神经功能,疗效显著,值得推广。Objective To study the effects of mild hypothermia therapy combined with small bone window intracranial hematoma removal on neuronal cytokines and vasoactive factors in patients with severe hypertensive cerebral hemorrhage.Methods A total of 62 patients with severe hypertensive cerebral hemorrhage admitted in our hospital from January 2020 to January 2023 were selected and divided into control group and observation group according to different treatment schemes,with 31 cases in each group.The control group was treated with small bone window intracranial hematoma removal,and the observation group was received with mild hypothermia therapy on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the volume of cerebral hematoma in the observation group was smaller than that in the control group,and the intracranial pressure was lower than that in the control group(P<0.05).After treatment,the levels of neuron-specific enolase(NSE),neuropeptide Y(NPY),endothelin(ET)and arginine vasopressin(AVP)in the observation group were lower than those in the control group(P<0.05).After treatment,the National Institutes of Health Stroke Scale(NIHSS)score of the observation group was lower than that of the control group,and the Glasgow Coma Scale(GCS)score was higher than that of the control group(P<0.05).Conclusion Mild hypothermia therapy combined with small bone window intracranial hematoma removal can effectively decrease the volume of cerebral hematoma in patients with severe hypertensive cerebral hemorrhage,reduce intracranial pressure and levels of neuronal cytokines and vasoactive factors,and improve neurological function,with significant curative effect,which is worthy of promotion.

关 键 词：高血压脑出血 亚低温治疗 小骨窗颅内血肿清除术 神经细胞因子 血管活性因子 

分 类 号：R743.34[医药卫生—神经病学与精神病学]