闭式冲洗留置负压引流结合全程冲洗技术治疗颌面间隙感染的效果及对sTREM-1、HMGB-1的影响  

Effect of closed irrigation indwelling negative pressure drainage combined with whole-process irrigation technique in the treatment of maxillofacial space infection and its influences on sTREM-1 and HMGB-1

作　　者：秦东泽 QIN Dongze(Hanzhong Central Hospital,Hanzhong 723000,China)

机构地区：[1]汉中市中心医院,陕西汉中723000

出　　处：《临床医学研究与实践》2024年第24期106-109,共4页Clinical Research and Practice

摘　　要：目的探讨闭式冲洗留置负压引流结合全程冲洗技术治疗颌面间隙感染的效果及对可溶性髓样细胞触发受体-1(sTREM-1)、高迁移率族蛋白B-1(HMGB-1)的影响。方法选取2020年5月至2022年5月收治的90例颌面间隙感染患者为研究对象,按照随机数字表法将其分为对照组与观察组,各45例。对照组采用传统切开引流术治疗,观察组采用闭式冲洗留置负压引流结合全程冲洗技术治疗。比较两组的治疗效果。结果观察组的治疗总有效率为93.33%,高于对照组的75.56%,差异具有统计学意义(P<0.05)。治疗前,两组的sTREM-1、HMGB-1水平比较,差异无统计学意义(P>0.05);治疗后,观察组的sTREM-1、HMGB-1水平低于对照组,差异具有统计学意义(P<0.05)。治疗前,两组的脓肿直径、张口度、视觉模拟量表(VAS)评分比较,差异无统计学意义(P>0.05);治疗后,观察组的脓肿直径、VAS评分低于对照组,张口度高于对照组,差异具有统计学意义(P<0.05)。结论闭式冲洗留置负压引流结合全程冲洗技术治疗颌面间隙感染,不仅能够提升整体治疗效果,还可降低sTREM-1、HMGB-1水平,减轻肿胀、疼痛及张口受限程度,值得推广。Objective To explore the effect of closed irrigation indwelling negative pressure drainage combined with whole-process irrigation technique in the treatment of maxillofacial space infection and its influences on soluble triggering receptor expressed on myeloid cells-1(sTREM-1)and high mobility group box-1 protein(HMGB-1).Methods A total of 90 patients with maxillofacial space infection admitted from May 2020 to May 2022 were selected as the research objects and divided into control group and observation group according to the random number table method,with 45 cases in each group.The control group was treated with traditional incision and drainage,and the observation group was treated with closed irrigation indwelling negative pressure drainage combined with whole-process irrigation technique.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was 93.33%,which was higher than 75.56%in the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of sTREM-1 and HMGB-1 between the two groups(P>0.05);after treatment,the levels of sTREM-1 and HMGB-1 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in abscess diameter,mouth opening degree and Visual Analogue Scale(VAS)score between the two groups(P>0.05);after treatment,the abscess diameter and VAS score of the observation group were lower than those of the control group,and the mouth opening degree was higher than that of the control group,the differences were statistically significant(P<0.05).Conclusion Closed irrigation indwelling negative pressure drainage combined with whole-process irrigation technique in the treatment of maxillofacial space infection can not only improve the overall treatment effect,but also reduce the levels of sTREM-1 and HMGB-1,and reduce the degree of swel

关 键 词：闭式冲洗留置负压引流 全程冲洗技术 颌面间隙感染 

分 类 号：R782.3[医药卫生—口腔医学]