视网膜光凝联合雷珠单抗玻璃体腔注射治疗糖尿病黄斑水肿的有效性及安全性  

Efficacy and safety of retinal photocoagulation combined with intravitreal injection of ranibizumab in the treatment of diabetic macular edema

作　　者：陈美芹 刘欣 郭永兰 CHEN Meiqin;LIU Xin;GUO Yongan(Ophthalmology Department,Henan Hongli Hospital,Xinxiang 453400;Ophthalmology Department,the Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]河南宏力医院眼科,河南新乡453400 [2]郑州大学第五附属医院眼科,河南郑州450000

出　　处：《临床医学研究与实践》2024年第24期115-118,共4页Clinical Research and Practice

摘　　要：目的分析视网膜光凝联合雷珠单抗玻璃体腔注射治疗糖尿病黄斑水肿患者的有效性及安全性。方法选取2019年1月至2022年6月收治的98例糖尿病黄斑水肿患者为研究对象,随机将其分为常规组(49例,雷珠单抗玻璃体腔注射治疗)和观察组(49例,视网膜光凝+雷珠单抗玻璃体腔注射治疗)。比较两组的治疗效果。结果观察组的治疗总有效率高于常规组(P<0.05)。第3次治疗后第2天(T_(3))~第3次治疗后30 d(T_(4)),观察组的裸眼视力(UCVA)、最佳矫正视力(BCVA)均高于常规组(P<0.05);首次治疗后第2天(T_(1))~T_(4),观察组的黄斑中心凹视网膜厚度低于常规组(P<0.05)。治疗后,观察组的荧光渗漏面积、阻力指数(RI)低于常规组,收缩期峰值流速(PSV)、舒张末期峰值流速(EDV)高于常规组(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论视网膜光凝联合雷珠单抗玻璃体腔注射治疗糖尿病黄斑水肿可有效降低患眼黄斑中心视网膜厚度,缩小荧光渗漏面积,改善患者眼动脉血流动力学指标,且不会增加不良反应,从而取得安全、理想的效果。Objective To analyze the efficacy and safety of retinal photocoagulation combined with intravitreal injection of ranibizumab in the treatment of patients with diabetic macular edema.Methods A total of 98 patients with diabetic macular edema admitted from January 2019 to June 2022 were selected as the research objects,and the patients were randomly divided into conventional group(49 cases,intravitreal injection of ranibizumab)and observation group(49 cases,retinal photocoagulation+intravitreal injection of ranibizumab).The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the conventional group(P<0.05).From the second day after the third treatment(T_(3))to 30 d after the third treatment(T_(4)),the uncorrected visual acuity(UCVA)and best corrected visual acuity(BCVA)in the observation group were higher than those in the conventional group(P<0.05);from the second day after the first treatment(T_(1))to T_(4),the macular fovealretinal thickness of the observation group was lower than that of the conventional group(P<0.05).After treatment,the fluorescence leakage area and resistance index(RI)in the observation group were lower than those in the conventional group,and the peak systolic velocity(PSV)and end diastolic velocity(EDV)were higher than those in the conventional group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Retinal photocoagulation combined with intravitreal injection of ranibizumab in the treatment of diabetic macular edema can effectively reduce the macular fovealretinal thickness of the affected eye,reduce the fluorescence leakage area,improve the hemodynamic indexes of the ophthalmic artery of the patients,and do not increase the adverse reactions,so as to achieve the safe and ideal effect.

关 键 词：视网膜光凝 雷珠单抗注射液 糖尿病 黄斑水肿 

分 类 号：R774.1[医药卫生—眼科]