菖葛补阳还五汤辅助西药常规治疗急性脑梗死临床研究  

Clinical Study on Changge Buyang Huanwu Decoction Assisting Conventional Western Medicine for Acute Cerebral Infarction

作　　者：马正兴 邵烈培 全燕燕 MA Zhengxing;SHAO Liepei;QUAN Yanyan(Department of Internal Medicine,Dongyang Huayuan Tian's Hospital,Dongyang Zhejiang 322121,China)

机构地区：[1]东阳花园田氏医院内科,浙江东阳322121

出　　处：《新中医》2024年第16期37-41,共5页New Chinese Medicine

摘　　要：目的:菖葛补阳还五汤辅助西药常规治疗急性脑梗死(ACI)的临床疗效。方法:按随机数字表法将108例ACI患者分为治疗组与对照组,每组54例。对照组给予降压降脂、抗血小板聚集、营养脑神经等西药常规治疗,治疗组在对照组基础上联合菖葛补阳还五汤治疗。治疗2周后,比较2组临床疗效、血液黏度、血清炎症因子[白细胞介素-6 (IL-6)、超敏C-反应蛋白(hs-CRP)]水平、神经功能缺损程度[美国国立卫生研究院卒中量表(NIHSS)]及日常生活能力[改良Barthel指数(MBI)]。结果:治疗后,治疗组总有效率为94.44%,对照组为77.78%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组血浆黏度、全血黏度低切、全血黏度高切水平均较治疗前下降(P<0.05),且治疗组3项指标均低于对照组(P<0.05)。治疗后,2组血清IL-6、hs-CRP水平均较治疗前降低(P<0.05),且治疗组IL-6、hs-CRP水平均低于对照组(P<0.05)。治疗后,2组NIHSS评分较治疗前降低(P<0.05),MBI评分较治疗前升高(P<0.05);且治疗组NIHSS评分低于对照组(P<0.05),MBI评分高于对照组(P<0.05)。结论:菖葛补阳还五汤辅助西药常规治疗ACI疗效确切,可改善患者血液黏度,减轻炎症反应,改善神经功能缺损症状,提高患者日常生活能力。Objective:To observe the clinical effect of Changge Buyang Huanwu Decoction assisting conventional western medicine on acute cerebral infarction(ACI).Methods:A total of 108 ACI patients were divided into the treatment group and the control group according to the random number table method,with 54 cases in each group.The control group was treated with conventional western medicine for antihypertension,lipid-lowering,anti-platelet aggregation,nutrition of brain nerve,and the treatment group was additionally treated with Changge Buyang Huanwu Decoction based on the treatment of the control group.After two weeks of treatment,the clinical effects,blood viscosity,levels of serum inflammatory factors[interleukin-6(IL-6)and hyper sensitive C-reactive protein(hs-CRP)],degree of neurological impairment[scores of National Institute of Health Stroke Scale(NIHSS)]and activity of daily living[scores of Modified Barthel Index(MBI)]were compared between the two groups.Results:After treatment,the total effective rate was 94.44%in the treatment group and 77.78%in the control group,the difference being significant(P<0.05).After treatment,the levels of blood viscosity,low-shear whole blood viscosity and high-shear whole blood viscosity in the two groups were reduced when compared with those before treatment(P<0.05),and the above three levels in the treatment group were lower than those in the control group(P<0.05).After treatment,the levels of serum IL-6 and hs-CRP in the two groups were declined when compared with those before treatment(P<0.05),and the above two levels in the treatment group were lower than those in the control group(P<0.05).After treatment,the NIHSS scores in the two groups were decreased when compared with those before treatment(P<0.05),and the MBI scores were enhanced when compared with those before treatment(P<0.05);the NIHSS score in the treatment group was lower than that in the control group(P<0.05),and the MBI score was higher than that in the control group(P<0.05).Conclusion:Changge Buyang Huanwu Decoction

关 键 词：急性脑梗死 葛根补阳还五汤 美国国立卫生研究院卒中量表 改良BARTHEL指数 炎症因子 

分 类 号：R743.33[医药卫生—神经病学与精神病学]