Correlations of transcranial sonography of substantia nigra characteristics with MRI iron deposition on substantia nigra in patients with Parkinson disease  

帕金森病患者经颅黑质超声特征与MRI黑质铁沉积表现的相关性

作　　者：ZOU Quan CHEN Fei MENG Wenyu ZHENG Hong 邹全;陈飞;孟文玉;郑红(兰州大学第一医院超声医学科,甘肃兰州730000)

机构地区：[1]Department of Ultrasound Medicine,the First Hospital of Lanzhou University,Lanzhou 730000,China

出　　处：《中国医学影像技术》2024年第8期1160-1163,共4页Chinese Journal of Medical Imaging Technology

摘　　要：Objective To explore the correlations of transcranial sonography of substantia nigra(SN-TCS)characteristics with MRI iron deposition on substantia nigra in patients with Parkinson disease(PD).Methods Data of SN-TCS and craniocerebral MRI in 120 PD patients were retrospectively analyzed.The patients were divided into iron deposition positive group(positive group,n=46)and iron deposition negative group(negative group,n=74)according to quantitative susceptibility mapping(QSM)value.Then parameters of SN-TCS and MRI were compared between groups(both P<0.05),and correlation analysis were also performed.Results The proportion of high echo positive,strong echo area and QSM value of substantia nigra,as well as of hyper-substantia nigra area/midbrain area(S/M)in positive group were all higher than those in negative group(all P<0.001).No significant difference of midbrain area was found between groups(P>0.05).Strong echo area of substantia nigra and S/M based on SN-TCS were both low-medium positively correlated with substantia nigra QSM value showed on MRI(r=0.497,0.529,both P<0.001).Conclusion SN-TCS characteristics of PD patients were correlated with MRI iron deposition on substantia nigra,among which strong echo area and S/M were valuable for evaluating iron deposition on substantia nigra.目的观察帕金森病(PD)经颅黑质超声(SN-TCS)特征与MRI黑质铁沉积的相关性。方法回顾性分析120例PD患者SN-TCS及颅脑MRI,根据黑质定量磁化率成像(QSM)测值将患者归入铁沉积阳性组(n=46,阳性组)及铁沉积阴性组(n=74,阴性组);比较2组SN-TCS及MRI参数并行相关性分析。结果阳性组黑质超声高回声阳性占比、强回声面积、QSM值,以及黑质强回声面积与中脑面积比值(S/M)均高于阴性组(P均<0.001);组间中脑面积差异无统计学意义(P>0.05)。SN-TCS所见黑质强回声面积及S/M均与MRI黑质QSM值呈低-中度正相关(r=0.497、0.529,P均<0.001)。结论PD患者SN-TCS特征与MRI黑质铁沉积存在相关性;其中,黑质强回声面积及S/M对评估黑质铁沉积具有一定价值。

关 键 词：Parkinson disease substantia nigra IRON ULTRASONOGRAPHY magnetic resonance imaging 

分 类 号：R742.5[医药卫生—神经病学与精神病学] R445[医药卫生—临床医学]