Research progresses of resting-state functional MRI in mild cognitive impairment and Alzheimer's disease  

静息态功能MRI用于轻度认知功能障碍及阿尔茨海默病研究进展

作　　者：DUAN Huanqin LI Linqin QIU Lihua 段欢芹;李琳钦;邱丽华(川北医学院附属医院放射科,四川南充637000;宜宾市第二人民医院医学影像中心,四川宜宾644000;成都中医药大学医学与生命科学学院,四川成都611137;宜宾市第二人民医院临床医学研究与转化中心神经影像大数据研究中心,四川宜宾644000)

机构地区：[1]Department of Radiology,the Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China [2]Department of Medical Imaging Center,Second People's Hospital of Yibin,Yibin 644000,China [3]School of Medical and Life Sciences,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China [4]Neuroimaging Big Data Research Center,Clinical Medical Research and Transformation Center,Second People's Hospital of Yibin,Yibin 644000,China

出　　处：《中国医学影像技术》2024年第8期1254-1257,共4页Chinese Journal of Medical Imaging Technology

基　　金：国家重点研发计划(2022YFC2009900、2022YFC2009901);四川省卫生健康委员会科技项目(23LCYJ021)。

摘　　要：Alzheimer's disease(AD)is a prevalent neurodegenerative disease characterized by cognitive decline in the early stage.Mild cognitive impairment(MCI)is considered as an intermediate stage between normal aging and AD.In recent years,studies related to resting-state functional MRI(rs-fMRI)indicated that the occurrence and development process of MCI and AD might be closely linked to spontaneous brain activity and alterations in functional connectivity among brain regions,and rs-fMRI could provide important reference for specific diagnosis and early treatment of MCI and AD.The research progresses of rs-fMRI for MCI and AD were reviewed in this article.阿尔茨海默病(AD)为常见神经退行性疾病,早期主要表现为认知能力下降;轻度认知功能障碍(MCI)是介于正常衰老与AD之间的过渡状态。近年来,静息态功能MRI(rs-fMRI)相关研究揭示了MCI及AD发生、发展过程可能与脑区自发活动及脑区间功能连接变化密切相关,而rs-fMRI可为特异性诊断及早期治疗MCI及AD提供重要参考。本文就rs-fMRI用于MCI及AD研究进展进行综述。

关 键 词：Alzheimer disease cognition disorders magnetic resonance imaging 

分 类 号：R742[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]