左氧氟沙星三联疗法与阿莫西林三联疗法治疗消化性溃疡的效果分析  

Analysis of the Therapeutic Effects of Levofloxacin Triple Therapy and Amoxicillin Triple Therapy in the Treatment of Peptic Ulcers

作　　者：庄译达 ZHUANG Yida(Department of Gastroenterology,Quanzhou Quangang District Hospital,Quanzhou 362800,China)

机构地区：[1]泉州市泉港区医院消化内科,泉州362800

出　　处：《中国医药指南》2024年第24期92-94,共3页Guide of China Medicine

摘　　要：目的探讨左氧氟沙星三联疗法与阿莫西林三联疗法在消化性溃疡中的治疗效果。方法选取诊断为消化性溃疡的86例患者,诊治时间2022年9月至2023年9月。以抽签法随机分成两组,各43例。对照组选择的方案为阿莫西林、克拉霉素、奥美拉唑三联方案,观察组选择左氧氟沙星、克拉霉素、奥美拉唑三联方案。比较两组治疗疗效、幽门螺杆菌(Hp)根治率、不良反应、胃肠道功能指标、复发情况。结果观察组治疗总有效率97.67%(42/43),对照组治疗总有效率72.09%(31/43),观察组治疗总有效率高于对照组(P<0.05)。观察组Hp根治率93.02%(40/43),对照组Hp根治率69.77%(30/43),观察组Hp根治率高于对照组(P<0.05)。观察组不良反应率6.98%(3/43),对照组不良反应率4.65%(2/43),两组对比无统计学差异(P>0.05)。治疗前两组患者胃泌素、胃动素指标对比无统计学差异(P>0.05);治疗后观察组胃泌素低于对照组,胃动素高于对照组(P<0.05)。观察组复发率为4.65%,对照组复发率为20.93%。观察组复发率低于对照组(P<0.05)。结论左氧氟沙星的三联方案在消化性溃疡的治疗中表现优于阿莫西林的三联方案,能够提升Hp根除效果,调节胃肠道激素的分泌,并且具有良好的安全性,能够减少疾病复发。Objective To explore the therapeutic effects of levofloxacin triple therapy and amoxicillin triple therapy in the treatment of peptic ulcers.Methods Eighty-six patients diagnosed with peptic ulcers were selected,and the diagnosis and treatment period was from September 2022 to September 2023.Randomly divide into two groups using a lottery method,with 43 cases in each group.The control group chose a triple regimen of amoxicillin,clarithromycin,and omeprazole,while the observation group chose a triple regimen of levofloxacin,clarithromycin,and omeprazole.Compare the treatment efficacy,Helicobacter pylori(Hp)eradication rate,adverse reactions,gastrointestinal function indicators,and recurrence between two groups.Results The total effective rate of the observation group was 97.67%(42/43),while the total effective rate of the control group was 72.09%(31/43).The total effective rate of the observation group was higher than that of the control group(P<0.05).The Hp curative rate in the observation group was 93.02%(40/43),while in the control group it was 69.77%(30/43).The observation group had a higher Hp curative rate than the control group(P<0.05).The adverse reaction rate in the observation group was 6.98%(3/43),while the adverse reaction rate in the control group was 4.65%(2/43).The two groups were compared(P>0.05).Comparison of gastrin and motilin indicators between the two groups of patients before treatment(P>0.05).After treatment,the observation group had lower levels of gastrin than the control group,and higher levels of motilin than the control group(P<0.05).The recurrence rate of the observation group was 4.65%,while the recurrence rate of the control group was 20.93%.The recurrence rate of the observation group was lower than that of the control group(P<0.05).Conclusions The triple regimen of levofloxacin performs better than the triple regimen of amoxicillin in the treatment of peptic ulcers.It can improve the eradication effect of Hp,regulate the secretion of gastrointestinal hormones,and has good safety,re

关 键 词：左氧氟沙星 阿莫西林 三联方案 消化性溃疡 胃肠道功能 

分 类 号：R573.1[医药卫生—消化系统]