畜禽金黄色葡萄球菌流行现状和中草药防控进展  

Current situation of Staphylococcus aureus infection in livestock and poultry and progress in the prevention and control with Chinese herbal medicines

作　　者：张文静 吕若一 修德冕 蔡子雯 王婧 孙志刚 司晓慧 孙英健[1,2] 刘晓晔[1,2] ZHANG Wenjing;LÜRuoyi;XIU Demian;CAI Ziwen;WANG Jing;SUN Zhigang;SI Xiaohui;SUN Yingjian*;LIU Xiaoye(Beijing Key Laboratory of Veterinary Medicine(Traditional Chinese Medicine),Beijing University of Agriculture,Beijing 102206,China;School of Animal Science and Technology,Beijing University of Agriculture,Beijing 102206,China)

机构地区：[1]北京农学院兽医学(中医药)北京市重点实验室,北京102206 [2]北京农学院动物科学技术学院,北京102206

出　　处：《微生物学通报》2024年第8期2753-2770,共18页Microbiology China

基　　金：北京市自然科学基金(6212003,6224060);北京农学院青年教师科研创新能力提升计划(QJKC2022028);北京农学院科技创新“火花行动”支持计划(BUA-HHXD2022007);北京市属高校分类发展项目(11000024T000002961733)。

摘　　要：金黄色葡萄球菌(Staphylococcus aureus)是常见的重要人畜共患条件致病菌,在社区和畜禽环境之间广泛传播,引发严重的兽医公共卫生问题。耐药金黄色葡萄球菌的频繁出现导致以抗生素为主的抗菌策略停滞不前,为响应我国减抗替抗政策,大批减抗替抗中草药抗菌药物已经投入临床前研究。本文通过归纳畜禽金黄色葡萄球感染情况、菌株耐药现状与耐药菌株流行特点,总结了畜禽金黄色葡萄球菌感染防控策略,并分析了中草药防控机制和靶点,为临床研究中草药抗菌策略提供研究内容。Staphylococcus aureus,a common major zoonotic opportunistic pathogen,spreads widely in the community and the livestock and poultry environment,seriously threatening veterinary public health.The frequent occurrence of drug-resistant strains of S.aureus has posed a challenge to the antimicrobial strategies based on antibiotics.In response to the Chinese policy of reducing and substituting antibiotics,a large number of Chinese herbal medicines as the alternatives of antibiotics have been put into clinical research.This paper summarized the S.aureus infection situation,current status of drug resistance,and epidemic characteristics of drug-resistant strains in livestock and poultry,summarized the prevention and control strategies.Furthermore,this paper analyzed the mechanisms and targets of Chinese herbal medicines in the prevention and control of this pathogen,providing research contents for clinical research on the antibacterial strategies of Chinese herbal medicines.

关 键 词：金黄色葡萄球菌 感染情况 耐药现状 中草药 

分 类 号：S855.11[农业科学—临床兽医学]