解郁和胃汤联合三联疗法对胃食管反流病患者神经肽类物质、胃动力调节激素的影响  

Effect of Jieyu and Wei Decoction combined with triple therapy on neuropeptide substance and gastric motility regulating hormone in patients with gastroesophageal reflux disease

作　　者：申甜甜 张艳 钱小丽 SHEN Tiantian;ZHANG Yan;QIAN Xiaoli(Surgical ICU,Hai’an People’s Hospital,Hai’an Jiangsu 226600,China)

机构地区：[1]海安市人民医院外科ICU,江苏海安226600

出　　处：《四川中医》2024年第8期112-115,共4页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:观察解郁和胃汤联合三联疗法对胃食管反流病患者神经肽类物质、胃动力调节激素的影响。方法:选取我院于2018年5月~2020年6月收治的胃食管反流病患者134例,根据治疗方案分为两组。对照组采用三联疗法治疗,观察组采用解郁和胃汤联合三联疗法治疗。统计两组总有效率,记录两组中医症候积分、神经肽类物质、胃动力调节激素及食管下括约肌压力(LESP)及其长度(LESL)变化。结果:与治疗前比较,两组的酸反流、胃灼热等主症和胸骨后痛、胀腹感、胃脘痛、嗳气、多怒、善饥等次症下降,且观察组治疗后中医症候积分较对照组低(P<0.05)。与治疗前比较,两组的胃泌素(GAS)、胃动素(MTL)、生长激素释放肽(Ghrelin)上升,P物质(SP)、降钙素基因相关肽(CGRP)、血管活性肠肽(VIP)下降,且观察组治疗后GAS、MTL、Ghrelin较对照组高,神经肽类物质指标、VIP较对照组低(P<0.05)。与治疗前比较,两组的LESP及LESL上升,且观察组治疗后LESP及LESL较对照组高(P<0.05)。观察组胃镜检查有效率高于对照组,有统计学意义(P<0.05)。结论:解郁和胃汤联合三联疗法治疗胃食管反流病可调节患者神经肽类物质、胃动力调节激素的表达,减轻症状,改善食管压力,提高疗效。Objective To observe the effect of Jieyu and Wei Tang combined with triple therapy on neuropeptide substances and gastric motility regulating hormones in patients with gastroesophageal reflux disease.Methods From May 2018~June 2020,134patients with gastroesophageal reflux disease were selected.The control group was treated with triple therapy,and the observation group was treated with Jieyu and Wei decoction combined with triple therapy.The total effective rate of the two groups was counted,and the changes of TCM symptom score,neuropeptide substance,gastric motility regulating hormone and lower esophageal sphincter pressure(LESP)and its length(LESL)were recorded.Results Compared with before treatment,the main syndromes of acid reflux,heartburn and sternal pain,abdominal distention,epigastric pain,belching,anger and hunger in the two groups decreased,and the syndrome score of TCM syndrome in the observation group after treatment was lower than that in the control group(P<0.05).Compared with pre-treatment,The gastrin(GAS),motilin(MTL)and growth hormone releasing peptide(Ghrelin)increased in both groups,P substances(SP),calcitonin gene-related peptides(CGRP),vasoactive intestinal peptides(VIP)decreased,And the GAS、MTL、Ghrelin in the observation group was higher than that in the control group,The index and VIP of neuropeptides were lower than those of control group(P<0.05).The LESP and LESL of the two groups were higher than that of the control group(P<0.05).Gastroscopy in the observation group was higher than that in the control group(P<0.05).Conclusion Jieyu and Wei decoction combined with triple therapy in the treatment of gastroesophageal reflux disease can regulate the expression of neuropeptides and gastric motility regulating hormones,reduce symptoms,improve esophageal pressure and improve the curative effect.

关 键 词：解郁和胃汤 三联疗法 胃食管反流病 神经肽类物质 胃动力调节激素 

分 类 号：R571[医药卫生—消化系统]