血清DKK-1、SDF-1α表达与多发性骨髓瘤骨病患者疾病严重程度的关系分析  

Relationship between Serum DKK-1,SDF-1αand Disease Severity in Patients with Multiple Myeloma Bone Disease

作　　者：周林林 李宁 路艳红 赵俊暕 孟爱国 ZHOU Lin-lin;LI Ning;LU Yan-hong;ZHAO Jun-jian;MENG Ai-guo(Department of Laboratory Medicine,Affiliated Hospital of North China University of Science and Technology,Tangshan,Hebei,063000,China)

机构地区：[1]华北理工大学附属医院检验科,河北唐山063000

出　　处：《现代生物医学进展》2024年第16期3162-3165,共4页Progress in Modern Biomedicine

基　　金：河北省医学科学研究课题计划项目(20200132)。

摘　　要：目的:探究血清Dickkopf-1(DKK-1)、基质细胞衍生因子-1α(SDF-1α)表达与多发性骨髓瘤骨患者疾病严重程度的关系。方法:以2022年1月~2023年12月62例多发性骨髓瘤骨病患者为研究组,以50例健康体检者为对照组,比较两组血清DKK-1、SDF-1α水平,分析血清DKK-1、SDF-1α水平对多发性骨髓瘤骨病的诊断价值及与疾病发生的关系;根据影像学检查MBD分级标准将患者分为轻度组(1~2级)及重度组(3~4级),分析血清DKK-1、SDF-1α水平对病情严重程度的评估价值。结果:研究组血清DKK-1、SDF-1α水平高于对照组(P<0.05);血清DKK-1、SDF-1α水平诊断多发性骨髓瘤骨病的AUC分别为0.771、0.717;重度组的血清DKK-1、SDF-1α水平高于轻度组(P<0.05);血清DKK-1、SDF-1α水平评估多发性骨髓瘤骨病病情严重程度的AUC分别为0.721、0.668。结论:多发性骨髓瘤骨病患者血清DKK-1、SDF-1α水平异常升高,且各指标联合检测对多发性骨髓瘤骨病诊断及病情严重程度具有评估价值。Objective:To explore the relationship between serum Dickkopf-1(DKK-1),stromal cell-derived factor-1α(SDF-1α)and disease severity in patients with multiple myeloma bone disease(MBD).Methods:A total of 62 patients with MBD and 50 healthy controls were enrolled as study group and control group between January 2022 and December 2023.The diagnostic value of serum DKK-1 and SDF-1αin MBD and their relationship with disease occurrence were analyzed.According to MBD grading standard in imaging examination,patients were divided into mild group(grade 1-2)and severe group(grade 3-4),and levels of serum DKK-1 and SDF-1αin the two groups were compared.The evaluation value of DKK-1 and SDF-1αfor disease severity was analyzed.Results:The levels of serum DKK-1 and SDF-1αin study group were higher than those in control group(P<0.05).AUC values of serum DKK-1 and SDF-1αin the diagnosis of MBD were 0.771 and 0.717,respectively.The levels of serum DKK-1 and SDF-1αin severe group were higher than those in mild group(P<0.05).AUC values of serum DKK-1 and SDF-1αfor evaluating the severity of MBD were 0.721 and 0.668,respectively.Conclusion:The levels of serum DKK-1 and SDF-1αare abnormally increased in patients with MBD.Combined detection of the two indexes is valuable in the diagnosis and severity evaluation of MBD.

关 键 词：多发性骨髓瘤骨病 DICKKOPF-1 基质细胞衍生因子-1Α 严重程度 诊断价值 

分 类 号：R733.3[医药卫生—肿瘤]