帕金森病患者血清Lp-PLA2、NT-3水平与快速眼动睡眠行为障碍的关系研究  

Relationship between Serum Lp-PLA2 and NT-3 Levels and Rapid Eye Movement Sleep Behavior Disorder in Patients with Parkinson's Disease

作　　者：叶琳琳 易琴 陈云清 邓小江 邹艳 YE Lin-lin;YI Qin;CHEN Yun-qing;DENG Xiao-jiang;ZOU Yan(Laboratory Department of Zigong Hospital Affiliated to Southwest Medical University,Zigong,Sichuan,643021,China;Neurology Department of Zigong Hospital Affiliated to Southwest Medical University,Zigong,Sichuan,643021,China)

机构地区：[1]西南医科大学附属自贡医院检验科,四川自贡643021 [2]西南医科大学附属自贡医院神经内科,四川自贡643021

出　　处：《现代生物医学进展》2024年第16期3196-3200,共5页Progress in Modern Biomedicine

基　　金：四川省教育厅科研基金项目(18ZB0504)。

摘　　要：目的:探讨帕金森病(PD)患者血清脂蛋白磷脂酶A2(Lp-PLA2)、神经营养因子-3(NT-3)水平与快速眼动睡眠行为障碍(RBD)的关系。方法:于2021年1月至2022年12月选择150例收治于西南医科大学附属自贡医院的PD患者作为PD组,与此同时选择55例在本院体检健康者作为对照组。采用酶联免疫吸附法(ELISA)检测血清Lp-PLA2、NT-3水平。PD组根据体征和RBD问卷-香港地区版(RBDQ-HK)评分分为RBD组和非RBD组,采用单因素及多因素Logistics回归分析PD患者伴发RBD的影响因素,采用受试者工作特征(ROC)曲线分析血清Lp-PLA2、NT-3对PD患者伴发RBD的预测效能。结果:对照组血清Lp-PLA2水平低于PD组(P<0.05),血清NT-3水平高于PD组(P<0.05)。单因素分析结果显示,PD患者伴发RBD与年龄、病程及血清Lp-PLA2、NT-3水平有关(P<0.05)。多因素Logistics回归分析显示,病程延长、Lp-PLA2水平升高是PD伴发RBD的独立危险因素,NT-3水平升高是PD伴发RBD的保护因素(P<0.05)。血清Lp-PLA2、NT-3及联合检测预测PD伴发RBD的曲线下面积(AUC)分别为0.830、0.766和0.866。结论:血清Lp-PLA2、NT-3与PD患者伴发RBD有关,其中血清Lp-PLA2升高是其独立危险因素,血清NT-3升高是保护因素,两项指标联合检测对PD伴发RBD具有较高的预测价值。Objective:To investigate the relationship between serum lipoprotein-associated phospholipaseA2(Lp-PLA2),neurotrophin-3(NT-3)levels and rapid eye movement sleep behavior disorder(RBD)in patients with Parkinson's disease(PD).Methods:150PD patients admitted to Zigong Hospital Affiliated to Southwest Medical University were selected as the PD group from January 2021 to December 2022,and at the same time,selected 55 healthy individuals who underwent physical examinations in our hospital as the control group.Enzyme linked immunosorbent assay(ELISA)was used to detect the serum levels of Lp-PLA2 and NT-3.The PD group was divided into RBD group and non RBD group based on the physical signs and RBD questionnaire Hong Kong region version(RBDQ-HK)score.Univariate and multivariate logistic regression were used to analyze the influencing factors in PD patients concomitant with RBD,and the predictive efficacy of serum Lp-PLA2 and NT-3 in PD patients concomitant with RBD was analyzed by receiver operating characteristic curve(ROC)curve.Results:The serum Lp-PLA2 level in the control group was lower than that in the PD group(P<0.05),and the serum NT-3 level was higher than that in the PD group(P<0.05).The results of univariate analysis showed that the PD patients concomitant with RBD was associated with age,course of disease,and serum levels of Lp-PLA2 and NT-3(P<0.05).Multivariate logistic regression analysis showed that prolonged course of disease,elevated Lp-PLA2 levels were independent risk factors for PD with RBD,while elevated NT-3 levels were protective factors for PD concomitant with RBD(P<0.05).The area under the curve(AUC)of serum Lp-PLA2,NT-3,and combined detection for predicting PD concomitant with RBD were 0.830,0.766,and 0.866,respectively.Conclusion:Serum Lp-PLA2 and NT-3 are associated with PD patients concomitant with RBD.Elevated serum Lp-PLA2 is an independent risk factor,while elevated serum NT-3 is a protective factor.The combined detection of these two indicators has high predictive value for PD concomitant w

关 键 词：帕金森病 脂蛋白磷脂酶A2 神经营养因子-3 快速眼动睡眠行为障碍 

分 类 号：R742.5[医药卫生—神经病学与精神病学]