虾青素合成工艺研究  

Study on Synthesis Process of Astaxanthin

作　　者：刘庆辉 LIU Qing-hui(Zhaoqing Juyuan Biochemical Co.,Ltd.,Guangdong Zhaoqing 526238,China)

机构地区：[1]肇庆巨元生化有限公司,广东肇庆526238

出　　处：《广州化工》2024年第15期35-38,45,共5页GuangZhou Chemical Industry

摘　　要：虾青素是一种含氧类胡萝卜素,是目前已实现工业化合成类胡萝卜素产品中的最高级别产物,合成难度最大,价值也最高。虾青素具有极强的抗氧化和淬灭活性氧作用,具有调节免疫系统和提高免疫力等功能,是维护人类和动物机体健康不可或缺的营养素,被广泛应用于食品、饲料、化妆品以及医药保健等领域,市场前景广阔。本文以4-氧代乙烯基-β-紫罗兰醇为起始原料,先硅醚化保护链上羟基,接着用三乙酸锰进行乙酰氧基化,之后进行脱保护和皂化,再进行溴代和Wittig反应制得虾青素,并考察了硅醚化反应中缚酸剂的选择,乙酰氧基化的反应溶剂、温度、催化剂等因素对反应收率的影响。Astaxanthin is a kind of oxygen-containing carotenoids,which is the highest level product in the industrialized synthesized carotenoid products,with the greatest difficulty in synthesis and the highest value.Astaxanthin has a strong antioxidant and quenching the role of reactive oxygen species,regulating the immune system and improve immunity and other functions,is to maintain the health of human and animal organisms indispensable nutrients,widely used in food,feed,cosmetics,and medicine and health care and other fields,the market has a broad prospect.4-oxovinyl-β-violanol was used as the starting material,and the hydroxyl group on the protected chain was firstly silicon etherified,followed by acetoxylation with manganese triacetate,and then deprotection and saponification,and then bromination and Wittig reaction were carried out to produce astaxanthin,and the effects of the selection of acid-binding agent in the silicon etherification reaction,reaction solvent of acetoxylation,temperature and catalysts on the reaction yields were investigated.

关 键 词：虾青素 硅醚化 乙酰氧基化 WITTIG反应 合成 

分 类 号：O629.4[理学—有机化学]