Association between the frontoparietal network,clinical symptoms and treatment response in individuals with untreated anorexia nervosa  

作　　者：Qianqian He Hui Zheng Jialin Zhang Ling Yue Qing Kang Cheng Lian Lei Guo Yan Chen Yanran Hu Yuping Wang Sufang Peng Zhen Wang Qiang Liu Jue Chen 

机构地区：[1]Department of Clinical Psychology,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai,China [2]Department of Clinical Psychology,Shanghai Pudong New Area Mental Health Center,Tongji University School of Medicine,Shanghai,China [3]Shanghai Key Laboratory of Psychotic Disorders,Brain Health Institute,National Center for Mental Disorders,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai,China [4]State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research,Bejing Normal University,Beijing,China

出　　处：《General Psychiatry》2024年第3期364-374,共11页综合精神医学（英文）

基　　金：supported by grants from Shanghai Jiao Tong University(YG2022ZD026);National Natural Science Foundation of China(81771461,82071545),Science and Technology Commission of Shanghai Municipality(20Y11906500);Shanghai Clinical Medical Research Center for Psychiatric and Psychological Disorders(19MC1911100);hospital-level research projects of Shanghai Mental Health Center(2020-YJ09,2020-QH-04);Youth Project of Shanghai Health Commission(20224Y0267).

摘　　要：Background Anorexia nervosa(AN)has been characterised as a psychiatric disorder associated with increased control.Currently,it remains difficult to predict treatment response in patients with AN.Their cognitive abilities are known to be resistant to treatment.It has been established that the frontoparietal control network(FPCN)is the direct counterpart of the executive control network.Therefore,the resting-state brain activity of the FPCN may serve as a biomarker to predict treatment response in AN.Aims The study aimed to investigate the association between resting-state functional connectivity(RSFC)of the FPCN,clinical symptoms and treatment response in patients with AN.Methods In this case-control study,79 female patients with AN and no prior treatment from the Shanghai Mental Health Center and 40 matched healthy controls(HCs)were recruited from January 2015 to March 2022.All participants completed the Questionnaire Versionof the Eating Disorder Examination(version 6.0)to assess the severity of their eating disorder symptoms.Additionally,RSFC data were obtained from all participants at baseline by functional magnetic resonance imaging.Patients with AN underwent routine outpatient treatment at the 4th and 12th week,during which time their clinical symptoms were evaluated using the same measures as at baseline.Results Among the 79 patients,40 completed the 4-week follow-up and 35 completed the 12-week follow-up.The RSFC from the right posterior parietal cortex(PPC)and dorsolateral prefrontal cortex(diPFC)increased in 79 patients with AN vs 40 HCs after controlling for depression and anxiety symptoms.By multiple linear regression,the RSFC of the PPC to the inferior frontal gyrus was found to be a significant factor for self-reported eating disorder symptoms at baseline and the treatment response to cognitive preoccupations about eating and body image,after controlling for age,age of onset and body mass index.The RSFC in the dIPFC to the middle temporal gyrus and the superior frontal gyrus may be significant factor

关 键 词：SYMPTOMS ROUTINE PREVENTION 

分 类 号：R749.7[医药卫生—神经病学与精神病学]