PI3K/Akt相关信号通路在神经细胞病理生理机制中的研究进展  

Progress in role of PI3K/Akt-related signaling pathways in pathophysiological mechanism of neural cells

作　　者：曾广红 朱彤 邹磊 周杰 ZENG Guanghong;ZHU Tong;ZOU Lei;ZHOU Jie(The First Clinical Medical College,Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China;The 940th Hospital of the People's Liberation Army Joint Service Support Force,Lanzhou 730050,China;The Second Clinical Medical College of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学第一临床医学院,甘肃兰州730000 [2]中国人民解放军联勤保障部队第九四〇医院,甘肃兰州730050 [3]兰州大学第二临床医学院,甘肃兰州730000

出　　处：《中国病理生理杂志》2024年第8期1529-1535,共7页Chinese Journal of Pathophysiology

基　　金：甘肃省卫生行业科研计划项目(No.GSWSKY2018-43);中国人民解放军联勤保障部队第九四〇医院研究生课题(No.2022yxky011);甘肃省科技计划项目(No.23JRRA532)。

摘　　要：磷脂酰激醇3-激酶(PI3K)/蛋白激酶B(PKB/Akt)信号通路在细胞生长、增殖、分化和凋亡等多种生物学功能中发挥着重要作用。PI3K/Akt相关信号通路研究众多,并且调控神经细胞发挥着不同或者相同的功能。本文综述了PI3K/Akt相关信号通路在神经细胞凋亡、自噬、氧化应激、神经炎症和其它病理生理机制中的作用研究进展。The phosphatidylinositol 3-kinase(PI3K)/protein kinase B(PKB/Akt)signaling pathway plays an important role in various biological processes,including cell growth,proliferation,differentiation,and apoptosis.The PI3K/Akt-related signaling pathways have been extensively studied,and they regulate neural cells to exert different or similar functions.This study reviews the research progress on PI3K/Akt-related signaling pathways in apoptosis,autophagy,oxidative stress,neuroinflammation,and other pathophysiological mechanisms in neural cells.

关 键 词：PI3K/AKT信号通路 神经细胞 细胞凋亡 自噬 氧化应激 

分 类 号：R742[医药卫生—神经病学与精神病学] Q421[医药卫生—临床医学] R363.2[生物学—神经生物学]