T细胞耗竭的研究进展  

Research progress in T-cell exhaustion

作　　者：张月霞 潘耀柱 ZHANG Yuexia;PAN Yaozhu(Graduate School of Qinghai University,Xining 810000,China;Department of Hematology,The 940th Hospital of Joint Logistics Support Force of Chinese Peoples Liberation Army,Lanzhou 730000,China)

机构地区：[1]青海大学研究生院,青海西宁810000 [2]中国人民解放军联勤保障部队第九四〇医院血液科,甘肃兰州730000

出　　处：《中国病理生理杂志》2024年第8期1548-1553,共6页Chinese Journal of Pathophysiology

基　　金：甘肃省卫生行业科研计划项目(No.GSWSKY-2019-63);西北民族大学重大需求培育项目(No.319202301950)。

摘　　要：T细胞耗竭指慢性感染和肿瘤患者体内T细胞功能的丧失。由于较长时间暴露于持续性抗原等炎症信号,T细胞逐渐失去效应功能,记忆T细胞特征也开始缺失。耗竭T细胞会影响肿瘤预后及病毒转归,耗竭的严重程度更会对肿瘤的预后带来一系列不良影响。随着肿瘤免疫治疗的广泛开展,深入理解T细胞耗竭机制以及通过逆转T细胞耗竭优化肿瘤免疫治疗方案已成为当前研究的热点。本文就T细胞耗竭发生机制、耗竭T细胞特征以及耗竭状态的逆转作一综述。T-cell exhaustion is the loss of T-cell function in patients with chronic infections and cancer.Prolonged exposure to inflammatory signals or persistent antigens causes T cells to gradually lose their effector function and memory characteristics.Exhausted T cells affect cancer prognosis and the outcome of viral infection,and the severity of exhaustion has a range of adverse effects on cancer prognosis.The extensive development of tumor immunotherapy has driven current research to understand the mechanism of T-cell exhaustion as well as to optimize tumor immunotherapy regimens by reversing T-cell exhaustion.This article reviews the mechanism of T-cell exhaustion,the characteristics of exhausted T cells,and the reversal of T-cell exhaustion status.

关 键 词：T细胞耗竭 抑制性受体 细胞因子 免疫治疗 

分 类 号：R730.51[医药卫生—肿瘤] R511[医药卫生—临床医学] R363