Senolystics from natural products for extending health and lifespan  

作　　者：Jia Chen De-Peng Ma Le-Min He Dong-Liang Yang 

机构地区：[1]School of Radiology,Shandong First Medical University&Shandong Academy of Medical Sciences,Tai’an 271016,China [2]Medical Science and Technology Innovation Center,Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan 250062,China [3]Key Laboratory of Flexible Electronics and Institute of Advanced Materials,School of Physical and Mathematical Sciences,Nanjing Tech University,Nanjing 211816,China.

出　　处：《Traditional Medicine Research》2024年第11期76-77,共2页TMR传统医学研究

基　　金：supported by Shandong Provincial Natural Science Foundation General Program(ZR2022MH226).

摘　　要：Senescence,a multifaceted cellular process,intricately regulates organismal aging by imposing irreversible growth arrest on cells.This phenomenon,characterized by altered gene expression and the accumulation of senescent cells,significantly contributes to age-related physiological decline and the onset of various age-associated pathologies[1].Cellular senescence,the irreversible cessation of cell division,is intricately linked to the aging process in individuals[2].As organisms age,the accumulation of senescent cells increases,contributing to tissue dysfunction and the development of age-related pathologies.Understanding the mechanisms underlying cellular senescence holds promise for elucidating the fundamental processes governing aging and may pave the way for targeted interventions to mitigate age-associated decline[3].

关 键 词：IRREVERSIBLE holds AGING 

分 类 号：R339.38[医药卫生—人体生理学]