阴道分娩对猪子宫韧带力学性能的影响  

Effects on the Mechanical Properties of Uterine Ligaments in Porcines During Vaginal Delivery

作　　者：王丽丽 刘然[1] WANG Lili;LIU Ran(College of Biomedical Engineering,Taiyuan University of Technology,Taiyuan 030024,China;Third Hospital of Shanxi Medical University(Shanxi Bethune Hospital,Shanxi Academy of Medical Sciences,Tongji Shanxi Hospital),Taiyuan 030032,China)

机构地区：[1]太原理工大学生物医学工程学院,太原030024 [2]山西医科大学第三医院(山西白求恩医院山西医学科学院同济山西医院),太原030032

出　　处：《医用生物力学》2024年第4期736-741,共6页Journal of Medical Biomechanics

基　　金：国家自然科学基金项目(12102286);山西省基础研究项目(20210302124251);中国博士后基金项目(2023M732143)。

摘　　要：目的研究阴道分娩对子宫骶韧带(uterosacral ligaments,USLs)和主韧带(cardinal ligaments,CLs)生物力学性能的影响,进而探讨阴道分娩对盆腔器官脱垂(pelvic organ prolapse,POP)的影响。方法选用成年母猪(已育母猪5头,未育母猪5头)作为动物模型,通过单轴拉伸实验测量离体母猪的USLs和CLs被动力学行为,分析分娩对USLs和CLs生物力学性能的影响。结果猪子宫韧带组织的被动力学行为呈非线性。无论分娩与否,右骶韧带的最大应力大于左骶韧带(P<0.05);分娩后,二者力学性能存在显著差异。未育母猪左主韧带最大应力略大于右主韧带(P<0.05);分娩后,两者差异降低(P>0.05)。USLs最大应力均大于CLs,表明USLs比CLs承受的张力更大,USLs在POP中起到关键性作用。结论研究结果为认识USLs和CLs力学特性提供参考,可以指导更好治疗方法的发展,如POP手术重建,也为预防POP发生提供理论基础。Objective To study the effects of vaginal delivery on the biomechanical properties of uterosacral ligaments(USLs)and cardinal ligaments(CLs)and to further explore the effects of vaginal delivery on pelvic organ prolapse(POP).Methods Adult sows(five parous and five nulliparous)were selected as animal models.The passive mechanical behavior of USLs and CLs in vitro was determined using uniaxial tensile experiments,and the effects of delivery on the biomechanical properties of USLs and CLs were analyzed.Results The passive mechanical behavior of the sow uterine ligaments was nonlinear.Regardless of delivery,the maximum stress of the right USLs was greater than that of the left USLs(P<0.05).After delivery,there were significant differences in the mechanical properties of the right and left USLs.The maximum stress of the left CLs in nulliparous sows was slightly greater than that of the right CLs(P<0.05),and the difference between the left and right CLs was reduced after delivery(P>0.05).The maximum stress of USLs was greater than that of CLs,indicating that USLs could be subjected to more tension than CLs and that USLs played a key role in POP.Conclusions This study provides a reference for understanding the mechanical properties of USLs and CLs,guidance for the development of better treatments such as reconstructive POP surgery,and a theoretical basis for preventing POP.

关 键 词：子宫骶韧带 主韧带 单轴拉伸测试 非线性 阴道分娩 

分 类 号：R318.01[医药卫生—生物医学工程]