高迁移率族蛋白1在抑郁症发病机制中的研究进展  

Research progress of high mobility group box 1 in the pathogenesis of depressive disorder

作　　者：许洪 司璐佳 谢银平 肖玲[1] 王高华[1] XU Hong;SI Lu-jia;XIE Yin-ping;XIAO Ling;WANG Gao-hua(Mental Health Center of Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院精神卫生中心,湖北省神经精神疾病研究所,430060

出　　处：《临床精神医学杂志》2024年第4期325-328,共4页Journal of Clinical Psychiatry

基　　金：国家自然科学基金(81871072);国家自然科学基金(82071523);武汉大学腾飞计划(TFLC2018001)。

摘　　要：抑郁症的病理机制复杂,研究表明神经炎症在抑郁症的病理机制中发挥着重要作用。高迁移率族蛋白1(high mobility group box 1,HMGB1)是一种广泛存在于哺乳动物真核细胞内的非组蛋白DNA结合蛋白,释放至胞外后可引发炎症性级联反应,继而导致抑郁症的发生。本文对HMGB1在抑郁症中可能涉及的病理机制进行综述,以期为后续研究提供借鉴。The pathological mechanism of depression is complicated,and studies have shown that neuroinflammation plays an important role in the pathological mechanism of depression.High mobility group box 1(HMGB1)is a non-histone DNA-binding protein that is widely expressed in eukaryocyte.When released to extracellular,it can trigger an inflammatory cascade,leading to the occurrence of depression.In this paper,the possible pathological mechanisms of HMGB1 in depression were reviewed,with a view to providing reference for future studies.

关 键 词：抑郁症 炎症 高迁移率族蛋白质类 

分 类 号：R749.4[医药卫生—神经病学与精神病学]