CyclinD1联合CA72-4、胃蛋白酶原、CEA检测在胃癌诊断中的价值  

Study on the diagnostic value of Cyclin D1 combined with CA72-4,pepsinogen and CEA in gastric cancer

作　　者：阮开学 陈芳 邓少琦 Ruan Kaixue;Chen Fang;Deng Shaoqi(Department of Gastroenterology,Dongguan Binhai Bay Central Hospital,Dongguan 523000;Department of Health Management,Dongguan Binhai Bay Central Hospital,Dongguan 523000)

机构地区：[1]东莞市滨海湾中心医院消化内科,广东东莞523000 [2]东莞市滨海湾中心医院健康管理科,广东东莞523000

出　　处：《中国现代医药杂志》2024年第8期10-14,共5页Modern Medicine Journal of China

基　　金：东莞市社会发展科技项目(编号:20211800900452)。

摘　　要：目的研究细胞周期蛋白D1(Cyclin D1)联合糖链抗原72-4(CA72-4)、胃蛋白酶原(PG)、癌胚抗原(CEA)检测在胃癌诊断中的价值。方法选取我院2021年10月~2023年3月内镜中心常规行内镜检查的疑似胃癌患者90例为研究对象,根据组织病理学检查结果将其分为良性胃疾病组(n=54)及胃癌组(n=36),入选患者均接受Cyclin D1、CA72-4、PG、CEA检测,比较各组上述指标表达水平,分析各项指标与胃癌病理分期的相关性,并绘制ROC曲线评价各指标对胃癌的诊断价值。结果胃癌组CEA、CA72-4、PGⅡ水平,Cyclin D1阳性率均高于良性胃疾病组,PGⅠ水平低于良性胃疾病组(P<0.05);TNM分期Ⅰ~Ⅳ期患者CEA、CA72-4、PGⅡ水平,Cyclin D1阳性率逐渐升高,PGⅠ水平逐渐降低(P<0.05);CEA、CA72-4、PGⅡ水平,Cyclin D1阳性率与病理分期呈正相关,PGⅠ水平与病理分期呈负相关(P<0.05);绘制ROC曲线发现,5项指标单独检测对胃癌均具有诊断价值,但相较而言,联合检测诊断胃癌的AUC更高,为0.906,约登指数为0.713,且敏感性、特异性均在85.00%以上。结论Cyclin D1联合CA72-4、PGⅠ、PGⅡ、CEA检测对胃癌诊断的敏感性较高,具有良好的诊断价值。Objective To study the diagnostic value of Cyclin D1 combined with carbohydrate antigen 72-4(CA72-4),pepsinogen(PG)and carcinoembryonic antigen(CEA)in gastric cancer.Methods From Oct 2021 to Mar 2023,90 patients with suspected gastric cancer who underwent routine endoscopic examination in the Endoscopy Center of our hospital were divided into the benign gastric disease group(54 cases)and the gastric cancer group(36 cases)according to the results of histopathological examination.All the patients were tested for Cyclin D1,CA72-4,PG and CEA,and the expression levels of the above indexes were compared and analyzed.Results The level of CEA,CA72-4,PGⅡand the positive expression of Cyclin D1 in the gastric cancer group were higher than those in the benign gastric disease group,and the level of PGⅠwas lower(P<0.05).The level of CEA,CA72-4,PGⅡand positive expression of Cyclin D1 increased gradually,while the level of PGⅠdecreased gradually(P<0.05).The level of CEA,CEA,CA72-4,PGⅡand positive expression of Cyclin D1 were positive correlated with pathological stages,while PGⅠwas negative correlated with pathological stages(P<0.05).ROC curve analysis showed that the individual detedion of 5 indexes had diagnostic value for gastric cancer,but the AUC of combined detection was higher,which was 0.906 and Yoden index was 0.713,and the sensitivity and specificity were above 85.00%.Conclusion The detection of Cyclin D1 combined with CA72-4,PGⅠ,PGⅡand CEA has high sensitivity which has diagnostic value for gastric cancer.

关 键 词：细胞周期蛋白D1 糖链抗原72-4 胃蛋白酶原 癌胚抗原 胃癌 

分 类 号：R735.2[医药卫生—肿瘤]