血清Hcy、D-D、IL-17水平与脑梗死患者病情及预后的相关性分析  

Correlation analysis of serum Hcy,D-D,IL-17 levels with the condition and prognosis of patients with cerebral infarction

作　　者：郭会月 王欣格 靳玫[1] Guo Hui-yue;Wang Xin-ge;Jin Mei(Department of Neurology,The Third Affiliated Hospital of Xinxiang Medical University,Xinxiang 453000,Henan,China)

机构地区：[1]新乡医学院第三附属医院神经内科,河南新乡453000

出　　处：《四川生理科学杂志》2024年第8期1720-1722,1789,共4页

摘　　要：目的:分析血清同型半胱氨酸(Homocysteine,Hcy)、D二聚体(D-dimer,D-D)、白介素-17(Interleukin-17,IL-17)水平与脑梗死患者病情及预后的相关性。方法:2020年11月至2023年2月择取我院脑梗死患者96例作为研究组,择取同期健康体检者96例作为对照组;随访6个月,根据改良Rankin量表评估患者预后,分为预后良好和预后不良患者。对比两组入院时及不同神经功能缺损程度、不同脑梗死病灶面积患者入院时血清各指标水平,并分析其相关性;对比不同预后患者入院时血清各指标水平,分析入院时血清各指标水平对脑梗死患者预后不良的预测价值。结果:研究组入院时血清Hcy、D-D、IL-17水平显著高于对照组(P<0.05);不同神经缺损程度、不同梗死面积患者入院时血清Hcy、D-D、IL-17水平比较,轻度<中度<重度、腔隙性梗死<小面积梗死<大面积梗死患者(P<0.05);入院时血清Hcy、D-D、IL-17均与神经缺损程度、脑梗死病灶面积均呈正相关(P<0.05);预后不良患者血清Hcy、D-D、IL-17水平显著高于预后良好患者(P<0.05);入院时血清Hcy、D-D、IL-17水平联合预测脑梗死患者预后不良的曲线下面积为0.788。结论:脑梗死患者血清Hcy、D-D、IL-17水平与病情程度及预后密切相关,认为临床检测其表达可作为评估患者病情及预后的有效指标,辅助临床诊疗。Objective:To analyze the correlation between serum homocysteine(Hcy),D-dimer(D-D)and interleukin-17(IL-17)levels and the condition and prognosis of patients with cerebral infarction.Methods:A total of 96 patients with cerebral infarction in our hospital from November 2020 to February 2023 were selected as the study group,and 96 healthy subjects in the same period were selected as the control group.According to the degree of neurological impairment,patients were divided into mild,moderate and severe patients,and according to the area of cerebral infarction patients were divided into lacunar infarction,small area infarction and large area infarction patients.After 6 months of follow-up,the patients were divided into good prognosis and poor prognosis according to the modified Rankin scale.Serum levels of Hcy,D-D and IL-17 were compared between the two groups at admission.The levels of serum indexes of patients with different degree of neurological impairment and different focal area of cerebral infarction were compared at admission,and the correlation was analyzed.By comparing the levels of serum indexes of patients with different prognosis at admission,the predictive value of serum indexes of patients with cerebral infarction at admission was analyzed.Results:The levels of serum Hcy,D-D and IL-17 in the study group were significantly higher than those in the control group(P<0.05).The levels of serum Hcy,D-D and IL-17 in patients with different degree of nerve defect were compared,mild<moderate<severe(P<0.05);Serum Hcy,D-D and IL-17 increased with the increase of infarct size,lacunar infarction<small infarct<large infarct patients(P<0.05).At admission,serum Hcy,D-D and IL-17 were positively correlated with the degree of nerve defect and the area of cerebral infarction(P<0.05).Serum levels of Hcy,D-D and IL-17 in patients with poor prognosis were significantly higher than those in patients with good prognosis(P<0.05).The Area Under the Curve of serum Hcy,D-D and IL-17 combined to predict poor prognosis in patients wi

关 键 词：HCY D-D IL-17 脑梗死 预后 

分 类 号：R743.33[医药卫生—神经病学与精神病学]