Injectable hydrogel-based drug delivery systems for enhancing the efficacy of radiation therapy:A review of recent advances  

作　　者：Ningyue Xu Jun Wang Lei Liu Changyang Gong 

机构地区：[1]Division of Head&Neck Tumor Multimodality Treatment,Cancer Center,West China Hospital,Sichuan University,Chengdu 610041,China [2]Department of Biotherapy,Cancer Center and State Key Laboratory of Biotherapy,West China Hospital,Sichuan University,Chengdu 610041,China

出　　处：《Chinese Chemical Letters》2024年第8期128-137,共10页中国化学快报（英文版）

基　　金：supported by Funds of Sichuan Province for Distinguished Young Scholar(No.2021JDJQ0037);Key Research and Development Program of Sichuan Province(No.2023YFS0153);1·3·5 project for disciplines of excellence,West China Hospital,Sichuan University(No.ZYYC08002).

摘　　要：Radiotherapy(RT)is a crucial treatment for cancer;however,its effectiveness is limited by adverse effects on normal tissues,radioresistance,and tumor recurrence.To overcome these challenges,hydrogels have been employed for delivery of radiosensitizers and other therapeutic agents.This review summarizes recent advancements in the application of hydrogel-based local drug delivery systems for improving the therapeutic efficacy of RT in cancer treatment.Firstly,we introduce the classification and properties of hydrogels.Next,we detail hydrogel-based platforms designed to enhance both external beam radiation therapy and brachytherapy.We also discuss hydrogels used in combination therapy involving RT and immunotherapy.Lastly,we highlight the challenges that hydrogels face in RT.By surveying the latest developments in hydrogel applications for RT,this review aims to provide insights into the development of more effective and targeted cancer therapies.

关 键 词：RADIOTHERAPY Drug delivery systems HYDROGEL Radiation sensitization Combination therapy 

分 类 号：R943[医药卫生—药剂学] TQ427.26[医药卫生—药学]