Recent advances in photochemistry for positron emission tomography imaging  

作　　者：Jing-Jing Zhang Lujun Lou Rui Lv Jiahui Chen Yinlong Li Guangwei Wu Lingchao Cai Steven H.Liang Zhen Chen 

机构地区：[1]Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources,Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-Forest Biomass,Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals,International Innovation Center for Forest Chemicals and Materials,College of Chemical Engineering,Nanjing Forestry University,Nanjing 210037,China [2]Department of Radiology and Imaging Sciences,Emory University,Atlanta,GA 30322,United States

出　　处：《Chinese Chemical Letters》2024年第8期149-162,共14页中国化学快报（英文版）

基　　金：the financial support from the Basic Research Program of Jiangsu Province(No.BK20220408).

摘　　要：As a powerful noninvasive imaging technology,positron emission tomography(PET)has been playing an important role in disease theranostics and drug discovery.The successful application of PET relies on not only the biological properties of PET tracers but also the availability of facile and efficient radiochemical reactions to enable practical production and widespread use of PET tracers.Most recently,photochemistry is emerging as a novel,mild and efficient approach to generating PET agents.In this review,we focus on the recent advances in newly developed photocatalytic radiochemical reactions,innovation on automated photochemical radiosynthesis modules,as well as implementation in late-stage radiolabeling and radio-pharmaceutical synthesis for PET imaging.We believe that this review will inspire the development of more promising radiolabeling protocols for the preparation of clinically useful PET agents.

关 键 词：Positron emission tomography(PET) FLUORINE-18 Carbon-11 PHOTOCATALYSIS AUTOMATION Late-stage functionalization 

分 类 号：TQ421.7[化学工程] O644.1[理学—物理化学]