Three positive charge nonapoptotic-induced photosensitizer with excellent water solubility for tumor therapy  

作　　者：Zhe Li Ping-Zhao Liang Li Xu Fei-Yu Yang Tian-Bing Ren Lin Yuan Xia Yin Xiao-Bing Zhang 

机构地区：[1]State Key Laboratory of Chemo/Biosensing and Chemometrics,College of Chemistry and Chemical Engineering,Hunan University,Changsha 410082,China

出　　处：《Chinese Chemical Letters》2024年第8期205-210,共6页中国化学快报（英文版）

基　　金：supported by the National Science Foundation of China(No.21890744);the National Key R&D Program of China(No.2019YFA0210100).

摘　　要：Photodynamic therapy(PDT)has emerged as a significant cancer therapy option.Currently,cation-based organic small molecule aggregation-induced emission(AIE)photosensitizers(PSs)attract the wide atten-tion of many scientists,due to improved reactive oxygen species(ROS)production after cationization.However,such PSs tend to localize only the mitochondria,limiting the death way of tumor cells(usu-ally apoptosis)during PDT process,which may affect the therapeutic effect under some circumstances.Herein,we designed a novel water-soluble three positive charge PS,TPAN-18F,which could be distributed uniformly in cell cytoplasm and had distribution in different sub-organelles(mitochondria,endoplasmic reticulum,lysosome).The experimental results showed that TPAN-18F-based PDT process can not only disrupt mitochondrial functions(reducing ATP production and destroying mitochondrial membrane po-tential),but also elevate the intracellular lipid peroxides(LPOs)level,which evoke the non-apoptotic death manner of tumor cells.Further,in vivo studies showed that TPAN-18F-based PDT could effectively inhibit tumor growth.Accordingly,we believe that the construction of TPAN-18F is suggestive for tumor non-apoptotic therapy.

关 键 词：WATER-SOLUBLE Three positive charge PHOTOSENSITIZER Nonapoptotic Tumor therapy 

分 类 号：R730.5[医药卫生—肿瘤]