HSA shrinkage optimizes the photostability of embedded dyes fundamentally to amplify their efficiency as photothermal materials  

作　　者：Yongkang Yue Zhou Xu Kaiqing Ma Fangjun Huo Xuemei Qin Kuanshou Zhang Caixia Yin 

机构地区：[1]Department Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education,Institute of Molecular Science,Shanxi University,Taiyuan 030006,China [2]Department Modern Research Center for Traditional Chinese Medicine,Shanxi University,Taiyuan 030006,China [3]Research Institute of Applied Chemistry,Shanxi University,Taiyuan 030006,China [4]State Key Laboratory of Quantum Optics and Quantum Optics Devices,Institute of Opto-Electronics,Shanxi University,Taiyuan 030006,China

出　　处：《Chinese Chemical Letters》2024年第8期211-216,共6页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(Nos.22277069,22074084);Program of the State Key Laboratory of Quantum Optics and Optical Quantum Devices of Shanxi University(No.KF202108).

摘　　要：Focused on the performance promotion of organic small molecular dyes based photothermal agents via non-chemical modification,we found that heat-assisted binding of human serum albumin(HSA)to the dye causes shrinkage of the protein and encapsulate the dye to form nanoparticles.This revolutionizes the photostability of small molecule dyes which further improves their photothermal conversion effi-ciency and tumor ablation performance as photothermal agents significantly.In this work,the obtained photothermal agent named HSA-P2-T could accumulate in tumor and induce 22℃enhancement of the tumor in xenograft models upon ultra-low dose(0.1 W/cm^(2))laser irradiation,which,as far as we know,is the lowest laser dose used in vivo photothermal therapy.Utilizing HSA-P2-T,we realized tumor ablation upon twice intravenous injections of the nanoparticles and four photothermal treatments.

关 键 词：Photothermal therapy Cyanine dyes PHOTOSTABILITY ALBUMIN ENCAPSULATION 

分 类 号：R730.5[医药卫生—肿瘤] TQ421.7[医药卫生—临床医学]