儿童糖尿病酮症酸中毒危险因素的研究进展  

Research Progress on Risk Factors of Diabetic Ketoacidosis in Children

作　　者：王瑞晔 王丽敏[1] 王金雪 杨占双[2] WANG Ruiye;WANG Limin;WANG Jinxue;YANG Zhanshuang(Department of Clinical Medical College,Jiamusi University,Jiamusi 154003,Heilongjiang,China;Department of Pediatrics,the First Affiliated Hospital of Jiamusi University,Jiamusi 154003,Heilongjiang,China)

机构地区：[1]佳木斯大学临床医学院,黑龙江佳木斯154003 [2]佳木斯大学附属第一医院儿科,黑龙江佳木斯154003

出　　处：《糖尿病新世界》2024年第10期190-194,共5页Diabetes New World

基　　金：佳木斯市市级科技计划创新激励类项目(SF2023JL0032)。

摘　　要：糖尿病酮症酸中毒(diabetic ketoacidosis,DKA)是儿童糖尿病的一种危及生命的急性并发症,主要发生在1型糖尿病中。近年来该疾病的发病率逐渐增高,且在儿童中发病率尤为明显,目前,该疾病已成为1型糖尿病患儿最主要的死亡原因。糖尿病酮症酸中毒的发病危险因素众多,国内对于该疾病预防的重视程度尚不够高,本文归纳了儿童DKA的危险因素,按照不可控制和可控制进行划分,包括年龄、性别、社会经济劣势、精神障碍、前驱感染、既往发作、糖化血红蛋白、C肽、血糖、对胰岛素的依从性差、延误诊断、胰岛素泵的使用等。通过对该疾病危险因素研究进展的归纳,旨在为儿童DKA的预防和诊治提供参考,以此来加强对该疾病的宣教及自我管理,减少患儿的患病率、再复发率及病死率,提高患儿生活质量。Diabetic ketoacidosis(DKA)is a life-threatening acute complication of diabetes mellitus in children,which occurs mainly in type 1 diabetes.In recent years,the incidence of the disease has increased year by year,espe-cially in children.At present,the disease has become the main cause of death in children with type 1 diabetes.There are many risk factors for the development of DKA,and the degree of attention paid to the prevention of this disease in China is not high enough.This paper summarizes the risk factors for DKA in children.They are divided according to uncontrollable and controllable,including age,gender,socioeconomic disadvantage,mental disorders,antecedent in-fections,previous episodes,glycated hemoglobin A1c,C-peptide,blood glucose,poor adherence to insulin,delayed di-agnosis,and insulin pump use.By summarizing the research progress on the risk factors of this disease,we aim to pro-vide a reference for the prevention and diagnosis of DKA in children,as a way to strengthen the education and self-management of this disease,reduce the prevalence,recurrence,and mortality rates,and improve the quality of life of the children.

关 键 词：儿童 青少年 糖尿病酮症酸中毒 危险因素 

分 类 号：R587.1[医药卫生—内分泌]