中青年无症状性脑梗死颈动脉特征及相关性分析  

Carotid Artery Characteristics and Correlation Analysis in Young and Middle-aged Adults with Silent Brain Infarction

作　　者：张微 罗庆玲 尹运佳[1] ZHANG Wei;LUO Qingling;YIN Yunjia(Harbin 242 Hospital,Heilongjiang Province)

机构地区：[1]哈尔滨二四二医院,黑龙江哈尔滨150066

出　　处：《航空航天医学杂志》2024年第8期897-901,共5页Journal of Aerospace medicine

基　　金：黑龙江卫健委科研基金项目(20220303070635)。

摘　　要：目的无症状性脑梗死是一种易被忽视的脑梗死类型,发病率高,误诊率较高。目前缺乏对中青年SBI患者与颈动脉硬化相关性研究。本研究分析中青年SBI患者颈动脉超声特征,并进一步探索及其与SBI发生的相关性。方法回顾性分析164例无神经缺损症状且完善头部磁共振检查的中青年患者的临床资料,根据MRI是否存在脑梗死病灶分为SBI组及非SBI组。比较两组年龄、性别、颈动脉超声检查结果(颈动脉硬化,颈动脉斑块类型)、实验室指标(总胆固醇、高密度脂蛋、甘油三酯、低密度脂蛋白)等。以SBI发病为因变量,以上述单因素分析差异有统计学意义的项目为自变量进行危险因素多因素Logistic回归分析。结果46例(50.5%)SBI患者存在颈动脉硬化,其中低回声斑块15例(32.6%),强回声斑块8例(17.4%),混合回声23例(50.0%)。中青年SBI组患者与非SBI组患者比较,年龄及颈动脉硬化比例高于非SBI组,差异具有统计学意义(P<0.05)。年龄对中青年SBI发生有促进作用(OR=1.08,OR95%CI:0.078-0.0.634,P<0.05),颈动脉硬化对中青年SBI发生有促进作用(OR=2.275,OR95%CI:1.122-4.613,P<0.05)。结论年龄、本次研究发现颈动脉硬化对中青年SBI发生有促进作用,是中青年SBI发病的危险因素。Objective Silent brain infarction is a easily overlooked type of cerebral infarction with high incidence and misdiagnosis rate.There is a lack of studies on the association with carotid artery stiffness in young and middle一aged SBI patients.This study analyzed the carotid ultrasound characteristics of young and middle-aged patients with SBI and further explored its correlation with the occurrence of SBI.Methods The clinical data of 164 young and middle-aged patients with perfect head MR examination were retrospectively analyzed and divided into SBI and non-SBI groups according to the presence of cerebral infarction on MRI.Age,sex,carotid ultrasound findings(carotid stiffness,carotid plaque type),laboratory indicators(high-density fat egg,total cholesterol,triglycerides,low-density lipoprotein)were compared.Multivariate Logistic regression analysis of risk factors was performed using the onset of asymptomatic cerebral infarction(SBI)as the dependent variable and the items with statistically significant differences in the above univariate analysis as the independent variables.Results The carotid artery stiffness was present in 46(50.5%)cases of SBI,including 15(32.6%)with hypoechoic plaques,8(17.4%)with strongly echoic plaques,and 23(50.0%)with mixed echoes.Compare·d with young and middle-aged SBI patients and non-SBI patients,the proportion of age and carotid stiffness was higher than the non-SBI group,and the difference was significant(P k0.05).Age promoted the development of SBI in young and middle-aged people(OR=1.08,OR95%CI:0.078-0.0.634,P<0.05),and carotid arteriosclerosis promoted the occurrence of SBI in young and middle-aged people(OR=2.275,OR95%CI:1.122-4.613,P<0.05).Conclusions Age and this study found that carotid arteriosclerosis promotes the occurrence of SBI and is a risk factor of young and middle-aged SBI.

关 键 词：无症状性脑梗死 中青年 影响因素 颈动脉硬化 

分 类 号：R741[医药卫生—神经病学与精神病学]