眼表重建技术的研究进展  

Research progress in ocular surface reconstruction

作　　者：刘涵[1] 张蓝月 沈强 Liu Han;Zhang Lanyue;Shen Qiang(Department of Ophthalmology,Chongqing University Jiangjin Hospital,Chongqing 402260,China)

机构地区：[1]重庆大学附属江津医院眼科,402260

出　　处：《中华眼科医学杂志（电子版）》2024年第3期182-186,共5页Chinese Journal of Ophthalmologic Medicine(Electronic Edition)

基　　金：重庆市自然科学基金面上项目(CSTB2023NSCQ-MSX1061,CSTB2023NSCQ-MSX0639);重庆市江津区科学技术局项目(Y2022017,Y2023016);2023年重庆市公共卫生重点专科(学科)建设项目。

摘　　要：眼表是一个复杂的结构,以稳态机制共同维持角膜的完整性;当眼表因疾病而改变时,其稳态就会失衡,导致不适感、角膜混浊及视力下降。传统的眼表疾病治疗方法主要包括滴眼液或手术移植,眼表重建疗法则是通过刺激眼表细胞增殖、维持眼表稳态及恢复眼表功能修复受损眼表。因此,促进角膜组织再生和改善泪膜稳定性对眼表疾病治疗具有重要价值,且较传统方法更有优势,具有一劳永逸的效果。基于此,本文中笔者就角膜缘干细胞缺乏、神经营养性角膜病、干眼及翼状胬肉等常见眼表疾病的眼表重建技术进展进行综述。The ocular surface is a complex structure that maintains the integrity of the cornea through a homeostatic mechanism.When the ocular surface changes due to disease,its homeostasis is lost,leading to discomfort,corneal opacity,and visual impairment.The traditional treatment methods for ocular surface diseases mainly include eye drops or transplantation surgery,while ocular surface reconstruction therapy repairs damaged ocular surfaces by stimulating the proliferation of ocular surface cells,maintaining ocular surface homeostasis,and restoring ocular surface function.It has been demonstrated that promoting corneal tissue regeneration and improving tear film stability to restore damaged ocular surfaces can improve the quality of life of patients with ocular surface,which has long-term advantages over traditional methods in treating ocular surface diseases.The new progress in ocular surface reconstruction methods based on common ocular surface diseases such as limbal stem cell deficiency,neurotrophic keratopathy,dry eye disease,and pterygium were reviewed in this paper.

关 键 词：眼表 眼表重建 角膜缘干细胞缺乏 神经营养性角膜病 干眼 翼状胬肉 

分 类 号：R779.6[医药卫生—眼科]