依达拉奉在急性脑梗死合并中重度阻塞性睡眠呼吸暂停低通气综合征中的应用价值  

Application of edaravone in acute cerebral infarction combined with moderate to severe obstructive sleep apnea hypopnea syndrome

作　　者：王霞 WANG Xia(Cangzhou Hejian Hospital of Traditional Chinese Medicine,Cangzhou,Hebei,062450,China)

机构地区：[1]沧州河间市中医院,河北沧州062450

出　　处：《中国冶金工业医学杂志》2024年第4期373-374,共2页Chinese Medical Journal of Metallurgical industry

摘　　要：目的探讨依达拉奉在老年急性脑梗死合并中重度阻塞性睡眠呼吸暂停低通气综合征患者中的效果。方法选取2021年6月—2022年6月我院收治的88例老年急性脑梗死合并中重度阻塞性睡眠呼吸暂停低通气综合征患者,根据电脑随机分组法将其分为对照组和研究组,每组各44例。对照组采用持续正压通气治疗,研究组在对照组基础上联合依达拉奉治疗。对比两组临床疗效及安全性。结果治疗后,研究组的炎症因子及细胞黏附因子、颅内动脉阻力指数、神经功能缺损及生活自理能力评分均优于对照组,两组比较差异均有统计学意义(t=9.418、6.827、12.537、19.152、2.192、5.681、5.396、4.491、11.253,均P<0.05);而两组不良反应发生率比较,差异无统计学意义(χ^(2)=0.715,P>0.05)。结论在治疗老年急性脑梗死合并中重度阻塞性睡眠呼吸暂停低通气综合征患者时,于持续正压通气治疗基础上联合依达拉奉能够提高临床疗效,改善患者的生活自理能力,保障临床用药安全性。ObjectiveTo explore the efficacy and of edaravone in the treatment of elderly patients with acute cerebral infarction combined with moderate to severe obstructive sleep apnea hypopnea syndrome.Methods From June 2021 to June 2022,88 elderly patients treated at our hospital for acute cerebral infarction combined with moderate to severe obstructive sleep apnea hypopnea syndrome were selected.They were randomly divided into a control group and a study group,with 44 patients in each group.The control group received continuous positive airway pressure therapy,while the study group received edaravone treatment in addition to the control group's therapy.Clinical efficacy and safety between the two groups were compared.Results After treatment,the study group showed significantly better outcomes in inflammatory and cell adhesion factors,iritiacranial arterial resistance index,neurological deficit,and activities of daily living scores compared to the control group,with statistically significant differences(t=9.418,6.827,12.537,19.152,2.192,5.681,5.396,4.491,11.253,all P<0.05).The incidence of adverse reactions between the two groups showed no significant difference(x=0.715,P>0.05).Conclusion Combining edaravone with continuous positive airway pressure therapy in elderly patients with acute cerebral infarction and moderate to severe obstructive sleep apnea hypopnea syndrome can enhance clinical efficacy,improve patient's independence in daily activities,and ensure the safety of clinical medication.

关 键 词：急性脑梗死 阻塞性睡眠呼吸暂停低通气综合征 老年患者 依达拉奉 持续正压通气 

分 类 号：R743.33[医药卫生—神经病学与精神病学]