北京地区单纯性肝囊肿的发病特点和病理生理研究分析  

Characteristics and pathophysiology of simple liver cysts in Beijing

作　　者：顾利国 郑亚民[2] 高翔[2] 蔡杰 黄跃[4] 周震[5] Gu Liguo;Zheng Yamin;Gao Xiang;Cai Jie;Huang Yue;Zhou Zhen(Department of Emergency,Liangxiang Hospital of Bejing Fangshan District,Beijing 102401,China;Department of General Surgery,Xuanwu Hospital,Capital Medical University,Beijing 100053,China;Department of Health Management,Xuanwu Hospital,Capital Medical University,Beijing 100053,China;Department of Information Center,Xuanwu Hospital,Capital Medical University,Beijing 100053,China;School of Biomedical Engineering,Capital Medical University,Beijing 100069,China)

机构地区：[1]北京市房山区良乡医院急诊科,北京102401 [2]首都医科大学宣武医院普外科,北京100053 [3]首都医科大学宣武医院健康管理科,北京100053 [4]首都医科大学宣武医院信息科,北京100053 [5]首都医科大学生物医学工程学院,北京100069

出　　处：《国际外科学杂志》2024年第8期528-534,F0004,共8页International Journal of Surgery

摘　　要：目的探索北京地区单纯性肝囊肿的发病特点和病理生理变化。方法采用回顾性队列研究的方法分析首都医科大学宣武医院健康管理科自2012年1月1日-2021年12月31日共10年的体检数据。选择重复2次及以上超声检查共计37 389名体检者的临床资料, 其中男性17 759名, 女性19 630名, 年龄(44.4±16.2)岁, 年龄范围22~103岁。通过重复超声检查确诊肝囊肿者3 431名, 同一体检者在肝囊肿形成后的数据为研究组(n=3 431), 形成囊肿前的数据为对照组(n=3 431)。观察指标包括:(1)肝囊肿的流行病学特点;(2)肝囊肿发病率的年龄分布规律;(3)肝囊肿发病率的性别分布规律;(4)肝囊肿的病理生理变化。正态分布的计量资料以均数±标准差(x±s)表示。偏态分布的计量资料以M(Q_(1), Q_(3))表示, 组间比较采用Wilcoxon符号秩和检验;计数资料组间比较采用χ^(2)检验。通过多因素Logistic回归分析总结肝囊肿致病的相关因素。结果肝囊肿的总体发病率为9.18%, 男性发病率为9.78%, 女性发病率为8.63%, 男性发病率大于女性。男性在70~79岁以上发病率出现轻度下降趋势, 其余年龄段男性和女性发病率均随着年龄增长而升高。多因素Logistic回归分析结果显示, 年龄(OR=1.01, 95%CI:1.01~1.02, P<0.01), 腰围(OR=1.02, 95%CI:1.01~1.02, P<0.01), 收缩压(OR=1.00, 95%CI:0.99~1.00, P=0.013), 谷丙转氨酶(OR=0.99, 95%CI:0.98~1.00, P<0.01), 谷草转氨酶(OR=1.03, 95%CI:1.02~1.04, P<0.01), 甘油三酯(OR=0.90, 95%CI:0.86~0.95, P<0.01), 高密度脂蛋白(OR=0.71, 95%CI:0.60~0.83, P<0.01), 尿酸(OR=1.00, 95%CI:1.00~1.00, P<0.01), 肌酐(OR=0.99, 95%CI:0.99~0.99, P<0.01)是肝囊肿发生的影响因素。结论肝囊肿的发病率随着年龄的增长呈线性升高趋势, 男性肝囊肿的发病率大于女性。年龄、腰围、收缩压、谷丙转氨酶、谷草转氨酶、甘油三酯、高密度脂蛋白、尿酸、肌酐可能与肝囊肿的发生发展存在相互�Objective To explore the onset characteristics and pathophysiological changes of simple liver cyst in Beijing.Methods A retrospective cohort study was used.The physical examination data of Department of Health Management of Xuanwu Hospital of Capital Medical University for 10 years from January 1,2012 to December 31,2021 were analyzed.Selected clinical data of 37389 subjects with 2 or more repeated ultrasound examinations,including 17759 males,19630 females,aged(44.4±16.2)years,ranged from 22-103 years.3431 cases hepatic cyst were confirmed by repeated ultrasound examination,the data of the liver cyst formation after the same physical examination were the study group(n=3431),and the data before cyst formation were the control group(n=3431).The observation indicators included:(1)the epidemiological characteristics of liver cysts;(2)the age distribution of the incidence of liver cysts;(3)the gender distribution of the incidence of liver cysts;(4)the pathophysiological changes of liver cysts.Measurement data of normal distribution were expressed as mean±standard deviation(x±s).The measurement data of skewed distribution were expressed as M(Q1,Q3),using Wilcoxon signed rank sum test for comparing groups and chi-square test for comparing count data.The factors associated with hepatic cyst pathogenesis were summarized by multivariate Logistic regression.Results The overall incidence of hepatic cysts was 9.18%,9.78%in males,8.63%in females,and the incidence of males was greater than that of females.The incidence of males over 70 to 79 years old decreased slightly,and the incidence in males and females in the other age groups increased with age.Results of multivariate Logistic analysis showed age(OR=1.01,95%CI:1.01-1.02,P<0.01),waist circumference(OR=1.02,95%CI:1.01-1.02,P<0.01),systolic blood pressure(OR=1.00,95%CI:0.99-1.00,P=0.013),ALT(OR=0.99,95%CI:0.98-1.00,P<0.01),AST(OR=1.03,95%CI:1.02-1.04,P<0.01),triglyceride lipids(OR=0.90,95%CI:0.86-0.95,P<0.01),HDL(0R=0.71,95%CI:0.60-0.83,P<0.01),uric acid(0R=1.00,95%CI:1.

关 键 词：囊肿 病理过程 生理过程 肝囊肿 发病特点 相关因素 

分 类 号：R575.8[医药卫生—消化系统]