天然产物调控氧化应激治疗脊髓损伤  

Natural products regulate oxidative stress in the treatment of spinal cord injury

作　　者：张孝炜 闫炳翰 仇道迪 薛海鹏[2] 谭国庆[2] 徐展望[2] Zhang Xiaowei;Yan Binghan;Qiu Daodi;Xue Haipeng;Tan Guoqing;Xu Zhanwang(Shandong University of Traditional Chinese Medicine,Jinan 250000,Shandong Province,China;Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250000,Shandong Province,China)

机构地区：[1]山东中医药大学,山东省济南市250000 [2]山东中医药大学附属医院,山东省济南市250000

出　　处：《中国组织工程研究》2025年第12期2560-2568,共9页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金面上项目(82174410),项目负责人:徐展望;山东省自然科学基金项目(ZR2020KH011),项目负责人:徐展望;山东省自然科学基金面上项目(ZR2020MH362),项目负责人:谭国庆;全国名老中医药专家传承工作室建设项目(国中医药人教函[2022]75号),项目负责人:徐展望。

摘　　要：背景:脊髓损伤是一种严重的神经系统疾病,常导致神经功能严重受损。在脊髓损伤后的病理过程中,氧化应激是一个重要环节,导致神经细胞死亡和功能丧失。近年来,天然产物因来源广泛、结构多样且生物活性丰富,逐渐在脊髓损伤后的氧化应激治疗中展现出潜在的应用价值。目的:讨论部分天然产物在脊髓损伤后氧化应激过程中的治疗作用以及相关作用机制,以期为脊髓损伤的抗氧化治疗提供新的思路和方向。方法:以“spinal cord injury,oxidative stress,anti-oxidation,natural products,natural compounds,polyphenols”“脊髓损伤,氧化应激,抗氧化,天然产物,天然化合物,多酚”为关键词,在PubMed、Web of Science、Embase、Cochrane、维普、CBM、万方和中国知网数据库检索自建库以来至2024年5月的相关文献。制定纳入和排除标准,通过阅读文献标题、摘要及全文内容进行筛选,最终纳入97篇相关文献。结果与结论:①天然产物如多酚类等可以依靠其结构中的酚羟基发挥直接清除氧化自由基的作用,减轻脊髓损伤后的氧化应激反应;②一些天然产物可以通过调控某些信号转导通路增强体内相关抗氧化酶的活性,减轻氧化应激;③部分天然产物可以通过增强自噬的方式减弱脊髓损伤后的氧化应激;④利用天然产物调控氧化应激可能成为今后临床上治疗脊髓损伤的有效工具。BACKGROUND:Spinal cord injury is a serious neurological disease that often results in severe neurological impairment.Oxidative stress is an important link in the pathological process after spinal cord injury,leading to neuronal cell death and loss of function.In recent years,natural products have shown potential application values in the treatment of oxidative stress after spinal cord injury due to their wide range of sources,diverse structures and rich biological activities.OBJECTIVE:To discuss the therapeutic effects of some natural products on oxidative stress after spinal cord injury and the related mechanisms,in order to provide new ideas and directions for antioxidant therapy of spinal cord injury.METHODS:“Spinal cord injury,oxidative stress,anti-oxidation,natural products,natural compounds,polyphenols”were used as the English and Chinese keywords in PubMed,Web of Science,Embase,Cochrane,VIP,CBM,WanFang,and CNKI databases to search relevant articles published from database inception to May 2024.Inclusion and exclusion criteria were developed,and 97 relevant articles were selected by reading titles,abstracts,and full texts.RESULTS AND CONCLUSION:Natural products such as polyphenols can directly scavenge oxidative free radicals by the phenol hydroxyl group in their structure,and alleviate oxidative stress after spinal cord injury.Some natural products can enhance the activity of relevant antioxidant enzymes in vivo and reduce oxidative stress by regulating certain signal transduction pathways.Some natural products can reduce oxidative stress after spinal cord injury by enhancing autophagy.The use of natural products to regulate oxidative stress may become an effective tool for the future clinical treatment of spinal cord injury.

关 键 词：脊髓损伤 氧化应激 抗氧化 天然产物 天然化合物 多酚 综述 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学] R322.81