免疫类器官在肿瘤免疫研究中的应用与挑战  

Application and challenge of immune-organoid in immuno-oncology

作　　者：王雪婷 高春记 张斌 WANG Xueting;GAO Chunji;ZHANG Bin(Senior Department of Hematology,The Fifth Medical Center of PLA General Hospital,Beijing 100071,China;School of Medicine,Nankai University,Tianjin 300071,China)

机构地区：[1]中国人民解放军总医院第五医学中心血液病医学部,北京100071 [2]南开大学医学院,天津300071

出　　处：《中国肿瘤生物治疗杂志》2024年第8期743-751,共9页Chinese Journal of Cancer Biotherapy

基　　金：军队生物安全项目(No.23SWAQ17)。

摘　　要：免疫治疗作为一种快速发展的治疗手段,使肿瘤治疗发生了革命性的变化,也使肿瘤免疫学研究领域重新焕发生机。免疫类器官因其能重建肿瘤免疫微环境,模拟免疫细胞的应答机制和相互作用而成为强有力的工具,在肿瘤免疫研究中得到了广泛的应用。免疫器官来源的免疫类器官,肿瘤类器官与免疫细胞共培养的新型免疫类器官模型为肿瘤免疫学研究提供了新的途径,可应用于肿瘤发生发展机制研究、药物筛选、研发肿瘤疫苗及指导个体化精准治疗等多个领域。本文总结免疫类器官的培养方法与现状,探讨了免疫类器官在肿瘤免疫中的广泛应用,对免疫类器官目前存在的不足进行了初步分析并对未来的发展方向进行了展望。Immunotherapy has emerged as a groundbreaking approach that has revolutionized tumor treatment and revitalized research in tumor immunology.At the forefront of this innovation is immune-organoid,which has become an indispensable tool in tumor immunology research.These models excel in reconstructing the tumor immune microenvironment,faithfully mimicking the response mechanisms and interactions of immune cells.Consequently,they have garnered widespread adoption in tumor immunology research.The innovative immune-organoid models encompass two primary categories:those derived from immune organs and those involving co-cultures of tumor organoids with immune cells.These models offer a versatile platform with applications spanning diverse domains,including the elucidation of tumorigenesis mechanisms,drug screening processes,the acceleration of cancer vaccine development,and the guidance of personalized therapeutic strategies.In this review,we provide a comprehensive summary of the current culture methods and status of immune-organoid.We also explore the wide application of immune-organoid in tumor immunology,while addressing the challenges they face and offering insights into future directions for this promising technology.

关 键 词：免疫类器官 肿瘤免疫 免疫疗法 肿瘤微环境 

分 类 号：R73-35[医药卫生—肿瘤] R730.3[医药卫生—临床医学]