Protection of Omicron Sub-Lineage Infection Against Reinfection with Another Omicron Sub-Lineage:Systematic Review,Meta-Analysis,and Meta-Regression-Worldwide,2022-2023  

作　　者：Xu Guo Zuyao Cheng Junhong Li Yudan Song Hui Zheng Yamin Wang Chao Ma Zijian Feng 

机构地区：[1]National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease,National Immunization Program,Chinese Center for Disease Control and Prevention,Beijing,China [2]Chinese Preventive Medicine Association,Beijing,China

出　　处：《China CDC weekly》2024年第26期624-628,I0001-I0009,共14页中国疾病预防控制中心周报（英文）

基　　金：Supported by the National Key Research and Development Program of China(2021YFC2301600);the National Natural Science Foundation of China(82341034);the Chinese Preventive Medicine Association’s COVID-19 Prevention and Control Modeling Research Project.

摘　　要：Summary What is already known about this topic?Both the decline in immunity over time and the evolution of the virus play a role in the level of protection offered by a prior infection.What is added by this report?Point estimates indicated variations in protection levels based on the initial infecting variant and the reinfecting variant.There was a consistent correlation between real-world protection,antigenic distance,and humoral immunity levels.Specifically,shorter antigenic distances and higher humoral immunity levels corresponded to enhanced real-world protection.What are the implications for public health practice?Our findings suggest that virological and immunological studies could help identify and assess the epidemic risk posed by new variants before they become dominant.Prompt incorporation of the latest variants into the antigen components of the coronavirus disease 2019(COVID-19)vaccines can significantly contribute to effective epidemic prevention and control measures.

关 键 词：IMMUNITY prevention shorter 

分 类 号：R563.1[医药卫生—呼吸系统] R18[医药卫生—内科学]