血浆致动脉硬化指数对不同年龄急性缺血性脑卒中血管内介入治疗短期预后的评估  

Evaluation of plasma atherogenic index on short-term prognosis of intravascularinterventional therapy in patients with acute ischemic stroke

作　　者：李淑晓 李兴超 王友芳 朱晓松 刘照营 车峰远[2] LI Shuxiao;LI Xingchao;WANG Youfang;ZHU Xiaosong;LIU Zhaoying;CHE Fengyuan(School of Clinical Medicine,Weifang Medical University,Weifang,Shandong 261000,China;不详)

机构地区：[1]潍坊医学院临床医学院,山东潍坊261000 [2]临沂市人民医院神经内科,山东临沂276002 [3]临沂市人民医院科研科,山东临沂276002 [4]临沂市人民医院重症医学科,山东临沂276002 [5]临沂市人民医院感染管理部,山东临沂276002 [6]锦州医科大学研究生培养基地(临沂市人民医院),山东临沂276002

出　　处：《中国临床研究》2024年第8期1234-1237,1243,共5页Chinese Journal of Clinical Research

基　　金：国家自然科学基金青年项目(82003435);山东省自然科学基金青年项目(ZR2020QH332);山东省医务职工科技创新计划项目(SDYWZGKCJH2022077)。

摘　　要：目的 探讨血浆致动脉硬化指数(AIP)对不同年龄段急性缺血性脑卒中(AIS)患者血管内介入治疗短期预后的评估作用。方法 筛选2020年1月至2022年12月在临沂市人民医院进行血管内介入治疗的AIS患者,根据年龄和AIP将患者分为低AIP中青年组(A组,50例),高AIP中青年组(B组,81例),低AIP老年组(C组,131例),高AIP老年组(D组,100例),以AIP为短期预后预测因子进行分析。结果 四组年龄、血糖、高血压病史、收缩压、入院NHISS评分、TC、TG、HDL-C、LDL-C、白蛋白、AIP比较差异有统计学意义(P<0.05)。A组、B组、C组、D组预后良好率分别为62.0%、40.7%、42.7%、38.0%,四组比较差异有统计学意义(χ^(2)=8.465,P=0.037),两两比较,B、C、D组的预后良好率低于A组,差异有统计学意义(P<0.05)。AIP和低入院NHISS评分是AIS患者预后良好的保护性因素(P<0.05)。AIP预测患者短期不良预后的最佳预测临界值为0.01,灵敏度为66.20%,特异度为51.30%,曲线下面积为0.611。结论 AIP是AIS患者血管内介入治疗短期预后的独立影响因素,有一定的临床应用价值。Objective To explore the role of plasma atherosclerotic index(AIP)in evaluating the short-term prognosis of endovascular intervention in acute ischemic stroke(AIS)patients of different age groups.Methods From January 2020 to December 2022,AIS patients undergoing intravascular interventional therapy in Linyi People's Hospital were selected and divided into low AIP with young and middle-aged group(group A,50 cases),high AIP with young and middle-aged group(group B,81 cases),low AIP with elderly group(group C,131 cases),and high AIP with elderly group(group D,100 cases)based on age and AIP.Statistical analysis was conducted using AIP as a short-term prognostic factor.Results There were significant differences in age,blood glucose,history of hypertension,systolic blood pressure,admission NHISS score,TC,TG,HDL-C,LDL-C,albumin and AIP among the four groups(P<0.05).The good prognosis rates of group A,B,C,and D were 62.0%,40.7%,42.7%,and 38.0%,respectively,with statistically significant difference among the four groups(χ^(2)=8.465,P=0.037).Pairwise comparison showed that the good prognosis rates of group B,C,and D were lower than those of group A(P<0.05).Lower AIP and admission NHISS score were protective factors for a good prognosis in AIS patients(P<0.05).The optimal critical value for predicting short-term adverse prognosis of patients with AIP was 0.01,with a sensitivity of 66.20%,a specificity of 51.30%,and a area under the curve of 0.611.Conclusion AIP is an independent influencing factor for the short-term prognosis of patients with AIS after endovascular intervention,and it can effectively predict the prognosis,which has a certain clinical application value.

关 键 词：血浆致动脉硬化指数 急性缺血性脑卒中 血管内介入治疗 预后 

分 类 号：R743.3[医药卫生—神经病学与精神病学]