辅酶Q10联合氟桂利嗪治疗偏头痛的临床疗效分析  

Analysis of clinical effi cacy of coenzyme Q10 combined with fl unarizine in the treatment of migraine

作　　者：王丽波 肖黎黎 舒鑫 张弟文[1] Wang Libo;Xiao Lili;Shu Xin;Zhang Diwen(The Third Hospital of Mianyang,Sichuan Mental Health Center,Mianyang Sichuan 621000,China)

机构地区：[1]四川省绵阳市第三人民医院·四川省精神卫生中心,四川绵阳621000

出　　处：《中国医刊》2024年第9期963-966,共4页Chinese Journal of Medicine

基　　金：四川省医学科研课题计划(S21A79)。

摘　　要：目的探究辅酶Q10联合氟桂利嗪治疗偏头痛的临床疗效。方法选取2023年1—6月四川省绵阳市第三人民医院收治的104例偏头痛患者为研究对象,采用随机数字表法分为对照组和观察组,每组52例。对照组给予氟桂利嗪治疗,观察组给予辅酶Q10联合氟桂利嗪治疗,两组患者均连续治疗6个月。比较分析两组患者治疗6个月后的临床疗效以及两组患者治疗期间的不良反应发生情况。比较分析两组患者治疗前及治疗6个月后的脑血流动力学指标(大脑后动脉的平均血流速度、大脑中动脉的平均血流速度、大脑前动脉的平均血流速度)、氧化应激状态[氧磷酶-1(PON-1)、氧化型低密度脂蛋白(ox-LDL)、芳香酯酶(ArE)]、偏头痛症状[偏头痛发作持续时间、偏头痛疼痛程度、偏头痛发作频次],采用数字等级评定量表(NRS)评估两组患者的偏头痛疼痛程度。结果治疗6个月后,观察组患者的临床总有效率高于对照组,差异有统计学意义(P<0.05)。两组患者治疗期间的不良反应总发生率比较差异无统计学意义(P>0.05)。治疗6个月后,两组患者大脑中动脉的平均血流速度、大脑前动脉的平均血流速度、大脑后动脉的平均血流速度、ox-LDL、偏头痛发作频次、偏头痛发作持续时间与治疗前比较均降低或缩短,且观察组低于或短于对照组,差异均有统计学意义(P<0.05)。治疗6个月后,两组患者的PON-1、ArE与治疗前比较均升高,且观察组高于对照组,差异均有统计学意义(P<0.05)。治疗前及治疗6个月后,两组患者的NRS评分比较差异均无统计学意义(P>0.05)。结论辅酶Q10联合氟桂利嗪治疗偏头痛的临床疗效显著,可有效改善患者的脑血流动力学与氧化应激状态,且安全性较好。Objective To explore the clinical efficacy of coenzyme Q10 combined with flunarizine in the treatment of migraine.Method A total of 104 migraine patients admitted to The Third Hospital of Mianyang in Sichuan Province from January to June 2023 were selected as the study objects.They were divided into control group and observation group by random number table method,with 52 cases in each group.The control group was treated with fl unarizine,and the observation group was treated with coenzyme Q10 combined with fl unarizine.Two groups were treated for 6 months.The clinical effi cacy in the two groups after 6 months of treatment and the occurrence of adverse reactions between the two groups were compared and analyzed.Cerebral hemodynamic indexes(mean blood fl ow velocity of posterior cerebral artery,mean blood fl ow velocity of middle cerebral artery,mean blood fl ow velocity of anterior cerebral artery),stress response indexes(PON-1,ox-LDL,ArE),migraine symptoms(migraine attack duration,severity of pain,migraine attack frequency)in the two groups were compared and analyzed before and after treatment.NRS was used to assess the degree of migraine pain in two groups.Result After 6 months of treatment,the total clinical effective rate in the observation group was higher than that in the control group,and the difference was statistically signifi cant(P<0.05).There was no signifi cant difference in the total incidence of adverse reactions between the two groups during treatment(P>0.05).After 6 months of treatment,the mean blood fl ow velocity of the middle cerebral artery,the mean blood fl ow velocity of the anterior cerebral artery,the mean blood fl ow velocity of the posterior cerebral artery,ox-LDL,migraine attack frequency and migraine attack duration in the two groups were all decreased or shortened compared with before treatment,and the observation group was lower or shorter than the control group,and the differences were statistically signifi cant(P<0.05).After 6 months of treatment,PON-1 and ArE in two groups were

关 键 词：偏头痛 辅酶Q10 氟桂利嗪 脑血流动力学 

分 类 号：R747.2[医药卫生—神经病学与精神病学]