奥洛他定联合氟米龙对过敏性结膜炎患者临床疗效及炎症因子水平的影响  

Effect of olotadine combined with flumirone on clinical efficacy and levels of inflammatory factors in patients with allergic conjunctivitis

作　　者：倪丽丽 潘英芬[1] 刘婷婷[1] NI Lili;PAN Yingfen;LIU Tingting(Department of Ophthalmology,Tai'an Maternal and Child Health Hospital,Tai'an,Shandong,271000,China)

机构地区：[1]泰安市妇幼保健院眼科,山东泰安271000

出　　处：《当代医学》2024年第13期38-42,共5页Contemporary Medicine

摘　　要：目的探讨奥洛他定联合氟米龙治疗过敏性结膜炎的临床疗效。方法选取2021年6月至2022年8月泰安市妇幼保健院收治的80例过敏性结膜炎患儿作为研究对象,根据不同治疗方法分为参照组与联合组,每组40例。参照组给予奥洛他定治疗,联合组给予奥洛他定联合氟米龙治疗,比较两组临床疗效、临床症状缓解时间、用药前后临床体征评分和泪液炎症细胞因子水平[C反应蛋白(CRP)、白细胞介素-4(IL-4)、白细胞介素-6(IL-6)]、鼻结膜炎生命质量调查表(RQLQ)评分、不良反应发生率。结果联合组治疗总有效率为97.50%,高于参照组的85.00%,但差异无统计学意义;联合眼部瘙痒、烧灼痛、异物感、结膜水肿、结膜充血缓解时间均短于参照组,差异有统计学意义(P<0.05);用药后,联合组眼睑水肿、角膜上皮化、分泌物、结膜乳头滤泡评分均低于参照组,差异有统计学意义(P<0.05);用药后,联合组泪液CRP、IL-4、IL-6水平均低于参照组,差异有统计学意义(P<0.05);联合组日常活动、行为问题、情感、睡眠、非鼻眼症状、鼻部症状、眼部症状评分均低于参照组,差异有统计学意义(P<0.05);两组不良反应发生率比较差异无统计学意义。结论奥洛他定联合氟米龙治疗过敏性结膜炎疗效显著,可明显抑制炎症细胞因子,加快症状缓解,减轻临床体征,还可改善泪液分泌功能,提高患儿生命质量,不良反应较少,值得临床推广应用。Objective To investigate the clinical efficacy of olatadine combined with flumirone in the treatment of allergic conjunctivitis.Methods 80 children with allergic conjunctivitis admitted to Tai'an Maternal and Child Health Hospital from June 2021 to August 2022 were selected as the research subjects,and they were divided into the reference group and the combined group according to different treatment methods,with 40 cases in each group.The reference group was treated with olotadine,and the combined group was treated with olotadine combined with flumirone.The clinical efficacy,clinical symptom relief time,clinical sign scores,tear inflammatory cytokine levels(C-reactive protein[CRP],interleukin-4[IL-4],interleukin-6[IL-6])before and after medication,rhinoconjunctivitis quality of life questionnaire(RQLQ)scores,and the incidence of adverse reactions were compared between the two groups.Results the total effective rate in the combined group was 97.50%,which was higher than 85.00%in the reference group,but there was no statistically significant difference;the symptom relief time pruritus,burning pain,foreign body sensation,conjunctival edema and conjunctival congestion in the combined group were shorter than those in the reference group,and the differences were statistically significant(P<0.05);after treatment,the scores of eyelid edema,corneal epithelialization,secretion and conjunctival papilla follicle in the combined group were lower than those in the reference group,and the differences were statistically significant(P<0.05);after medication,the levels of tears CRP,IL-4,IL-6 in the combined group were lower than those in the reference group,and the differences were statistically significant(P<0.05);the scores of daily activities,behavioral problems,emotion,sleep,non-nasal and eye symptoms,nasal symptoms and eye symptoms in the combined group were lower than those in the reference group,and the differences were statistically significant(P<0.05);there was no significant difference in the incidence of adverse reactio

关 键 词：过敏性结膜炎 奥洛他定 氟米龙 炎症细胞因子 

分 类 号：R777.31[医药卫生—眼科]