急诊肝动脉化疗栓塞术治疗自发性肝癌破裂出血患者的临床疗效和安全性  

Clinical efficacy and safety of emergency transcatheter arterial chemoembolization in the treatment of spontaneous rupture and hemorrhage of liver cancer

作　　者：彭辉 余俊 周薇 PENG Hui;YU Jun;ZHOU Wei(Department of Interventional Medicine,the First People's Hospital of Fuzhou,Fuzhou,Jiangxi,344000,China)

机构地区：[1]抚州市第一人民医院介入医学科,江西抚州344000

出　　处：《当代医学》2024年第13期154-156,共3页Contemporary Medicine

摘　　要：目的探讨急诊肝动脉化疗栓塞术(TACE)治疗自发性肝癌破裂出血患者的临床疗效和安全性。方法选取2021年1月至2022年3月抚州市第一人民医院收治的60例肝癌自发性破裂出血患者作为研究对象,根据治疗方法不同分为对照组与观察组,每组30例。对照组接受保守治疗,观察组在对照组基础上联合急诊TACE治疗,比较两组止血指标(止血成功率、治疗3 d后血红蛋白)、肿瘤标志物、并发症发生情况。结果观察组止血率、治疗3 d后血红蛋白水平均高于对照组,差异有统计学意义(P<0.05)。治疗后,两组甲胎蛋白(AFP)、糖类抗原19-9(CA19-9)水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组肝肾功能衰竭、骨髓抑制发生率均高于对照组,差异有统计学意义(P<0.05)。结论与保守治疗相比,急诊TACE治疗自发性肝癌破裂出血临床疗效显著,可迅速稳定患者的病情,有利于疾病预后,且安全性较高,值得临床推广应用。Objective To investigate the clinical efficacy and safety of emergency transcatheter arterial chemoembolization(TACE)in the treatment of patients with spontaneous rupture and hemorrhage of liver cancer.Methods 60 patients with spontaneous rupture and hemorrhage of liver cancer admitted to the First People's Hospital of Fuzhou from January 2021 to March 2022 were selected as the research subjects,they were divided into the control group and the observation group according to the different treatment methods,with 30 cases in each group.The control group received conservative treatment,the observation group was treated with emergency TACE on the basis of the control group.The hemostatic indexes(success rate of hemostasis,hemoglobin after 3 d of treatment),tumor markers and complications were compared between the two groups.Results The hemostasis rate and hemoglobin after 3 d of treatment in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of alpha-fetoprotrin(AFP)and carbohydrate antigen 19-9(CA19-9)of the two groups were lower than those before treatment,and the observation group was lower than the control group,the differences were statistically significant(P<0.05).The incidence of liver and kidney failure and bone marrow suppression in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Compared with conservative treatment,emergency TACE has significant clinical efficacy in the treatment of spontaneous liver cancer rupture and hemorrhage,which can quickly stabilize the patient's condition and is conducive to the prognosis of the disease,and has high safety,and is worthy of clinical promotion and application.

关 键 词：肝动脉化疗栓塞术 自发性肝癌破裂出血 临床疗效 血清肿瘤标志物 

分 类 号：R735.7[医药卫生—肿瘤]