The role of anesthesia in peri-operative neurocognitive disorders:Molecular mechanisms and preventive strategies  

作　　者：Ran Li Yun Zhang Qinxin Zhu Yili Wu Weihong Song 

机构地区：[1]The Second Affiliated Hospital and Yuying Children's Hospital,Institute of Aging,Key Laboratory of Alzheimer's Disease of Zhejiang Province,Wenzhou Medical University,Wenzhou325035,China [2]The National Clinical Research Center for Geriatric Disease,Xuanwu Hospital,Capital Medical University,Beijing 100053,China [3]Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine,Vision and Brain Health),Wenzhou 32500o0,China

出　　处：《Fundamental Research》2024年第4期797-805,共9页自然科学基础研究（英文版）

基　　金：the grants from the National Natural Science Foundation of China to WS(82150710557,82293642).

摘　　要：Peri-operative neurocognitive disorders(PNDs)include postoperative delirium(POD)and postoperative cognitive dysfunction(POCD).Children and the elderly are the two populations most vulnerable to the development of POD and POCD,which results in both high morbidity and mortality.There are many factors,including neuroinflammation and oxidative stress,that are associated with POD and POCD.General anesthesia is a major risk factor of PNDs.However,the molecular mechanisms of PNDs are poorly understood.Dexmedetomidine(DEX)is a useful sedative agent with analgesic properties,which significantly improves POCD in elderly patients.In this review,the current understanding of anesthesia in PNDs and the protective effects of DEX are summarized,and the underlying mechanisms are further discussed.

关 键 词：Peri-operative neurocognitive disorders General anesthesia Postoperative cognitive dysfunction Postoperative delirium DEXMEDETOMIDINE Alzheimer'sdisease 

分 类 号：R614[医药卫生—麻醉学]