Glutamatergic neurons of piriform cortex delay induction of inhalational general anesthesia  

作　　者：Liang Zhou Qipeng Ran Rulan Yi Huanyao Tang Yu Zhang Tian Yu 

机构地区：[1]Key Laboratory of Brain Science,Zunyi Medical University,Zunyi 563003,China [2]Department of Anesthesiology,Affiliated Hospital of Zunyi Medical University,Zunyi 563003,China [3]Guizhou Key Laboratory of Anesthesia and Organ Protection,Zunyi Medical University,Zunyi 563003,China

出　　处：《Fundamental Research》2024年第4期829-840,共12页自然科学基础研究（英文版）

基　　金：the National Natural Science Foundation of China(82060224,81971298,81571026);Scientific Project of Guizhou Province(Qian Comprehensive Basic Science[2020]1Y088,[2017]5733-066,[2020]-002);Joint Bidding Project by Zunyi City and Zunyi Medical University(ZSKH-HZ[2021]-194);PhD Research Startup Foundation of Zunyi Medical University(F-958).

摘　　要：Since their clinical application in the 1840s,the greatest mystery surrounding general anesthesia(GA)is how different kinds of general anesthetics cause reversible unconsciousness,and the precise neural mechanisms underlying the processes.Over past years,although many studies revealed the roles of cortex,thalamus,brainstem,especially the sleep-wake circuits in GA-induced loss of consciousness(LOC),the full picture of the neural circuit mechanism of GA is still largely unknown.Recent studies have focused on the importance of other brain regions.Here,we report that the activity of glutamatergic(Glu)neurons in the piriform cortex(PC),a critical brain region for odor encoding,began to increase during the LOC of GA and gradually recovered after recovery of consciousness.Chemical lesions of the anterior PC(APC)neurons accelerated the induction time of isoflurane anesthesia.Chemogenetic and optogenetic activation of APcGlu neurons prolonged isoflurane and sevoflurane anesthesia induction,whereas APcclu neuron inhibition displayed the opposite effects.Moreover,the modification of APcclu neurons did not affect the induction or emergence time of propofol GA.In addition,odor processing may be partially involved in the induction of isoflurane and sevofurane GA regulated by APCclu neurons.In conclusion,our findings reveal a critical role of APCGlu neurons in inhalational GA induction.

关 键 词：Piriform cortex Inhalationalgeneral anesthesia GLUTAMATERGIC Induction time ODOR 

分 类 号：R614[医药卫生—麻醉学]