GLUTAMATERGIC

作品数：33被引量：59H指数：5
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相关领域：医药卫生更多>>
相关作者：程乐平赖苗军阮列敏楼忠泽更多>>
相关机构：宁波市第一医院空军军医大学宁夏医科大学中国科学院上海生命科学研究院更多>>
相关期刊：《Frontiers in Biology》《Acta Pharmacologica Sinica》《Journal of Pharmacy and Pharmacology》《Journal of Polyphenols》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划北京市自然科学基金国家高技术研究发展计划更多>>
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Glutamatergic CYLD deletion leads to aberrant excitatory activity in the basolateral amygdala:association with enhanced cued fear expression
《Neural Regeneration Research》2025年第11期3259-3272,共14页Huidong Li Faqin Li Zhaoyi Chen Erwen Wu Xiaoxi Dai Danni Li Haojie An Shiyi Zeng Chunyan Wang Li Yang Cheng Long 
supported by the National Natural Science Foundation of China,Nos.32371065(to CL)and 32170950(to LY);the Natural Science Foundation of the Guangdong Province,No.2023A1515010899(to CL);the Science and Technology Projects in Guangzhou,Nos.2023A4J0578 and 2024A03J0180(to CW)。
Neuronal activity,synaptic transmission,and molecular changes in the basolateral amygdala play critical roles in fear memory.Cylindromatosis(CYLD)is a deubiquitinase that negatively regulates the nuclear factor kappa-...
关键词：basolateral amygdala cued fear expression cylindromatosis deubiquitinase glutamate receptor 1 glutamatergic neuron microglial activation N-methyl-D-aspartate receptor 1 neuronal activation synaptic transmission 
GPR17 modulates anxiety-like behaviors via basolateral amygdala to ventral hippocampal CA1 glutamatergic projection
《Acta Pharmaceutica Sinica B》2024年第11期4789-4805,共17页Ruizhe Nie Xinting Zhou Jiaru Fu Shanshan Hu Qilu Zhang Weikai Jiang Yizi Yan Xian Cao Danhua Yuan Yan Long Hao Hong Susu Tang 
National Natural Science Foundation of China(82373860 and 82071202 to Susu Tang,82173805 to Hao Hong);National Innovation and Entrepreneurship Training Program for Undergraduate(202410316198,China).
Anxiety disorders are one of the most epidemic and chronic psychiatric disorders.An incom-plete understanding of anxiety pathophysiology has limited the development of highly effective drugs against these disorders.GP...
关键词：GPR17 CRS Anxiety Basolateral amygdala VentralhippocampalCAl Glutamatergic neurons Glutamatergic projection CANGRELOR 
Glutamatergic Circuits in the Pedunculopontine Nucleus Modulate Multiple Motor Functions
《Neuroscience Bulletin》2024年第11期1713-1731,共19页Yanwang Huang Shangyi Wang Qingxiu Wang Chaowen Zheng Feng Yang Lei Wei Xintong Zhou Zuoren Wang 
support from the Optical Imaging Facility and the Animal Facility of the Institute of Neuroscience,Center for Excellence in Brain Science&Intelligence Technology,Chinese Academy of Sciences,supported by the STI2030-Major Projects(2022ZD0205100).
The functional role of glutamatergic(vGluT2)neurons in the pedunculopontine nucleus(PPN)in modulating motor activity remains controversial.Here,we demonstrated that the activity of vGluT2 neurons in the rostral PPN is...
关键词：Pedunculopontine nucleus Glutamatergic neuron Pause-and-play Caudal pontine reticular nucleus Anterior gigantocellular reticular nucleus Zona incerta 
Glutamatergic neurons of piriform cortex delay induction of inhalational general anesthesia被引量：1
《Fundamental Research》2024年第4期829-840,共12页Liang Zhou Qipeng Ran Rulan Yi Huanyao Tang Yu Zhang Tian Yu 
the National Natural Science Foundation of China(82060224,81971298,81571026);Scientific Project of Guizhou Province(Qian Comprehensive Basic Science[2020]1Y088,[2017]5733-066,[2020]-002);Joint Bidding Project by Zunyi City and Zunyi Medical University(ZSKH-HZ[2021]-194);PhD Research Startup Foundation of Zunyi Medical University(F-958).
Since their clinical application in the 1840s,the greatest mystery surrounding general anesthesia(GA)is how different kinds of general anesthetics cause reversible unconsciousness,and the precise neural mechanisms und...
关键词：Piriform cortex Inhalationalgeneral anesthesia GLUTAMATERGIC Induction time ODOR 
MDGA2 Constrains Glutamatergic Inputs Selectively onto CA1 Pyramidal Neurons to Optimize Neural Circuits for Plasticity,Memory,and Social Behavior
《Neuroscience Bulletin》2024年第7期887-904,共18页Xuehui Wang Donghui Lin Jie Jiang Yuhua Liu Xinyan Dong Jianchen Fan Lifen Gong Weida Shen Linghui Zeng Tonghui Xu Kewen Jiang Steven A.Connor Yicheng Xie 
supported by the National Natural Science Foundation of China(82001203,82173819,81871012,and 81571263);the Scientific Research Fund of Zhejiang Provincial Education Department(Y201839276);the Scientific Research Foundation of Zhejiang University City College(X-202103);the R&D Project of Zhejiang(2022C03034);the Natural Science Foundation of Zhejiang Province(LQ23C090001);a Canada Research Chair Award(P2018-0246).
Synapse organizers are essential for the development,transmission,and plasticity of synapses.Acting as rare synapse suppressors,the MAM domain containing glycosylphosphatidylinositol anchor(MDGA)proteins contributes t...
关键词：MDGA2 CA1 pyramidal neurons Glutamatergic inputs Synaptic plasticity MEMORY Social behaviors AUTISM Synapse organizers 
Small-molecule caspase-1 inhibitor CZL80 terminates refractory status epilepticus via inhibition of glutamatergic transmission
《Acta Pharmacologica Sinica》2024年第7期1381-1392,共12页Fei Wang Yu Wang Qing-yang Zhang Ke-yu Hu Ying-jie Song Lin Yang Fan Fei Ceng-lin Xu Sun-liang Cui Ye-ping Ruan Yi Wang Zhong Chen 
supported by grants from the National Natural Science Foundation of China (82330116 and 82022071);the Natural Science Foundation of Zhejiang Province (LD22H310003).
Status epilepticus(SE),a serious and often life-threatening medical emergency,is characterized by abnormally prolonged seizures.It is not effectively managed by present first-line anti-seizure medications and could re...
关键词：status epilepticus DIAZEPAM caspase-1 inhibitor therapeutic time window glutamatergic synaptic transmission 
Cyanidin-3-O-glucoside alleviates trimethyltin chloride-induced neurodegeneration by maintaining glutamate homeostasis through modulation of the gut microbiota被引量：1
《Food Science and Human Wellness》2024年第2期1093-1107,共15页Yu Xi Wenhui Li Junru Wang Meihong Yu Xiangquan Zeng He Li Jian Li 
supported by the National Natural Science Foundation of China(81903275);the fund of Cultivation Project of Double First-Class Disciplines of Food Science and Engineering,Beijing Technology&Business University(BTBUYXTD202203)。
Trimethyltin chloride(TMT)is a potent neurotoxin to cause neurodegeneration,especially in hippocampus.This study aimed to identify dietary components that can effectively attenuate TMT-induced neurodegeneration in hum...
关键词：Cyanidin-3-O-glucoside TRIMETHYLTIN NEURODEGENERATION Glutamatergic pathway Gut microbiota 
A subthalamo-parabrachial glutamatergic pathway is involved in stress-induced self-grooming in mice被引量：1
《Acta Pharmacologica Sinica》2023年第11期2169-2183,共15页Tao Jia Jing Chen Ying-di Wang Cheng Xiao Chun-yi Zhou 
supported by the National Natural Science Foundation of China 81971038(CYZ),82071231(CX),82171235(CYZ),82271293(CX),81870891(CX);the Fund for Jiangsu Province Specially-Appointed Professor(CX,CYZ),the Natural Science Foundation of Jiangsu Province(BK20211349,CYZ);the Leadership Program in Xuzhou Medical University(JBGS202203,CX);TJ and JC acknowledge the Postgraduate Innovation Program in Jiangsu Province(KYCX22_2936,KYCX22_2952).
Excessive self-grooming is an important behavioral phenotype of the stress response in rodents. Elucidating the neural circuit that regulates stress-induced self-grooming may suggest potential treatment to prevent mal...
关键词：STRESS emotional disorders SELF-GROOMING subthalamic nucleus lateral parabrachial nucleus glutamatergic neurons 
(+)-Borneol enantiomer ameliorates epileptic seizure via decreasing the excitability of glutamatergic transmission被引量：3
《Acta Pharmacologica Sinica》2023年第8期1600-1611,共12页Yu Wang Xiao-yun Qiu Jia-ying Liu Bei Tan Fei Wang Min-juan Sun Xu-hong Jiang Xu-ming Ji Ceng-lin Xu Yi Wang Zhong Chen 
supported by grants from the National Key R&D Program of China (2021ZD0202803 and 2020YFA0803902);the National Natural Science Foundation of China (82022071);the Natural Science Foundation of Zhejiang Province (LD22H310003);the Research Project of Zhejiang Chinese Medical University (2022JKJNTZ13).
Epilepsy is one common brain disorder,which is not well controlled by current pharmacotherapy.In this study we characterized the therapeutic potential of borneol,a plant-derived bicyclic monoterpene compound,in the tr...
关键词：epilepsy anti-seizure drug (+)-borneol valproate SUBICULUM glutamatergic synaptic transmission 
Noradrenergic, glutamatergic and dopaminergic systems are implicated in antidepressant-like effect of flavonoids extracted from okra (Abelmoschus esculentus [L.] Moench.) fruit in the forced swimming test
《Journal of Polyphenols》2022年第1期17-31,共15页Fuyuan Li Xiaozhuo Zhang Qianqian Mao Bo Wu Ying Jia Tingxu Yan 
This research was supported by Shenyang Scientific Project(No.F13-287-1-00);Liaoning Province Natural Science Foundation(No.2014020076).
Okra(Abelmoschus esculentus[L.]Moench.)is one of the most frequently used herbals in East or West Africa,and its various biological activities have been widely studied.Flavonoids extracted from many plants are reporte...
关键词：OKRA ANTIDEPRESSANT forced swimming test(FST) mechanism flavonoid compound 
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