Glutamatergic Circuits in the Pedunculopontine Nucleus Modulate Multiple Motor Functions  

作　　者：Yanwang Huang Shangyi Wang Qingxiu Wang Chaowen Zheng Feng Yang Lei Wei Xintong Zhou Zuoren Wang 

机构地区：[1]Institute of Neuroscience,State Key Laboratoryof Neuroscience,CAS Center for Excellence in Brain Scienceand Intelligence Technology,Chinese Academy of Sciences,Shanghai 200031,China [2]University of Chinese Academy of Sciences,Beijing 100049,China [3]School of Future Technology,University of ChineseAcademy of Sciences,Beijing 100049,China [4]School of Life Science and Technology,ShanghaiTech University,Shanghai 201210,China

出　　处：《Neuroscience Bulletin》2024年第11期1713-1731,共19页神经科学通报(英文版)

基　　金：support from the Optical Imaging Facility and the Animal Facility of the Institute of Neuroscience,Center for Excellence in Brain Science&Intelligence Technology,Chinese Academy of Sciences,supported by the STI2030-Major Projects(2022ZD0205100).

摘　　要：The functional role of glutamatergic(vGluT2)neurons in the pedunculopontine nucleus(PPN)in modulating motor activity remains controversial.Here,we demonstrated that the activity of vGluT2 neurons in the rostral PPN is correlated with locomotion and ipsilateral head-turning.Beyond these motor functions,we found that these rostral PPN-vGluT2 neurons remarkably respond to salient stimuli.Furthermore,we systematically traced the upstream and downstream projections of these neurons and identifed two downstream projections from these neurons to the caudal pontine reticular nucleus/anterior gigantocellular reticular nucleus(PnC/GiA)and the zona incerta(ZI).Our fndings indicate that the projections to the PnC/GiA inhibit movement,consistent with‘pause-and-play’behavior,whereas those to the ZI promote locomotion,and others respond to a new‘pause-switch-play’pattern.Collectively,these fndings elucidate the multifaceted infuence of the PPN on motor functions and provide a robust theoretical framework for understanding its physiological and potential therapeutic implications.

关 键 词：Pedunculopontine nucleus Glutamatergic neuron Pause-and-play Caudal pontine reticular nucleus Anterior gigantocellular reticular nucleus Zona incerta 

分 类 号：R741[医药卫生—神经病学与精神病学]