Cyanidin-3-O-glucoside alleviates trimethyltin chloride-induced neurodegeneration by maintaining glutamate homeostasis through modulation of the gut microbiota  

作　　者：Yu Xi Wenhui Li Junru Wang Meihong Yu Xiangquan Zeng He Li Jian Li 

机构地区：[1]Key Laboratory of Green and Low-Carbon Processing Technology for Plant-Based Food of China National Light Industry Council,Beijing Advanced Innovation Center for Food Nutrition and Human Health,Beijing Technology and Business University,Beijing 100048,China

出　　处：《Food Science and Human Wellness》2024年第2期1093-1107,共15页食品科学与人类健康（英文）

基　　金：supported by the National Natural Science Foundation of China(81903275);the fund of Cultivation Project of Double First-Class Disciplines of Food Science and Engineering,Beijing Technology&Business University(BTBUYXTD202203)。

摘　　要：Trimethyltin chloride(TMT)is a potent neurotoxin to cause neurodegeneration,especially in hippocampus.This study aimed to identify dietary components that can effectively attenuate TMT-induced neurodegeneration in humans.The predominant anthocyanin in human diets,cyanidin-3-O-glucoside(C3G,5 or 50 mg/kg),was given to mice for 16 days,and TMT(2.7 mg/kg)was injected intraperitoneally once on the eighth day.C3G(50 mg/kg)significantly alleviated TMT-induced seizures and subsequent cognitive impairment by ameliorating hippocampal neurodegeneration and synaptic dysfunction.Furthermore,C3G treatment restored glutamate homeostasis in brain and reversed glutamine synthetase(GS)inhibition in reactive astrogliosis and neuroinflammation,which are critical for C3G's neuroprotective effects.Notably,C3G decreased the lipopolysaccharide,tumor necrosis factor-α,interleukin-6,and interleukin-1βlevels in the mice,which potentially by modulating the relative abundance of Atopobiaceae and Lachnospiraceae in the gut.C3G may be a promising and practical dietary component for reducing TMT-induced neurodegeneration.

关 键 词：Cyanidin-3-O-glucoside TRIMETHYLTIN NEURODEGENERATION Glutamatergic pathway Gut microbiota 

分 类 号：TS201.4[轻工技术与工程—食品科学]