Multiple valence states of Fe boosting SERS activity of Fe_(3)O_(4) nanoparticles and enabling effective SERS-MRI bimodal cancer imaging  

作　　者：Jie Lin Xuehua Ma Anran Li Ozioma Udochukwu Akakuru Chunshu Pan Meng He Chenyang Yao Wenzhi Ren Yanying Li Dinghu Zhang Yi Cao Tianxiang Chen Aiguo Wu 

机构地区：[1]Cixi Institute of Biomedical Engineering,International Cooperation Base of Biomedical Materials Technology and Application,Chinese Academy of Science Key Laboratory of Magnetic Materials and Devices,Zhejiang Engineering Research Center for Biomedical Materials,Ningbo Institute of Materials Technology and Engineering,CAS,Ningbo315201,China [2]School of Engineering Medicine,Key Laboratory of Big Data-Based Precision Medicine(Beihang University),Ministry of Industry and Information Technology,Beihang University,Beijing100191,China [3]Advanced Energy Science and Technology Guangdong Laboratory,Huizhou 516000,China [4]University of Chinese Academy of Sciences,Bejing 100049,China

出　　处：《Fundamental Research》2024年第4期858-867,共10页自然科学基础研究（英文版）

基　　金：contributed equally to this work.

摘　　要：Developing novel nanoparticle-based bioprobes utilized in clinical settings with imaging resolutions ranging from cell to tissue levels is a major challenge for tumor diagnosis and treatment.Herein,an optimized strategy for designing a Fe_(3)O_(4)-based bioprobe for dual-modal cancer imaging based on surface-enhanced Raman scattering(SERS)and magnetic resonance imaging(MRI)is introduced.Excellent SERS activity of ultrasmall Fe_(3)O_(4) nanoparticles(NPs)was discovered,and a 5×10^(-9)M limit of detection for crystal violet molecules was successfully obtained.The high-efficiency interfacial photon-induced charge transfer in Fe_(3)O_(4) NPs was promoted by multiple electronic energy levels ascribed to the multiple valence states of Fe,which was observed using ultraviolet-visible diffuse reflectance spectroscopy.Density functional theory calculations were utilized to reveal that the narrow band gap and high electron density of states of ultrasmall Fe_(3)O_(4) NPs significantly boosted the vibronic coupling resonances in the SERS system upon illumination.The subtypes of cancer cells were accurately recognized via high-resolution SERS imaging in vitro using the prepared Feg Og-based bioprobe with high sensitivity and good specificity.Notably,Fe_(3)O_(4)-based bioprobes simultaneously exhibited T,-weighted MRI contrast enhancement with an active targeting capability for tumors in vivo.To the best of our knowledge,this is the first report on the use of pure semiconductor-based SERS-MRI dual-modal nanoprobes in tumor imaging in vivo and in vitro,which has been previously realized only using semiconductor-metal complex materials.The non-metallic materials with SERS-MRI dual-modal imaging established in this report are a promising cancer diagnostic platform,which not only showed excellent performance in early tumor diagnosis but also possesses great potential for image-guided tumor treatment.

关 键 词：Fe_(3)O_(4)NPs SERS-MRI dual-modal nanoprobes PICT Multiple valence states Cancer diagnosis 

分 类 号：R730[医药卫生—肿瘤]