维生素C与糖尿病视网膜病变相关研究  

Study on the correlation between vitamin C and diabetic retinopathy

作　　者：张晨[1] 胡彬 田艳明 Zhang Chen;Hu Bin;Tian Yan-ming(Xinjiang Medical University,Wulumuqi 830000,China;Shihezi University,Shihezi 830000,China;General Hospital of Xinjiang Military Region,Wulumuqi 830000,China)

机构地区：[1]新疆医科大学,乌鲁木齐830000 [2]石河子大学,乌鲁木齐830000 [3]新疆军区总医院眼科,乌鲁木齐830000

出　　处：《临床眼科杂志》2024年第4期369-372,共4页Journal of Clinical Ophthalmology

基　　金：新疆自然科学基金面上项目(2022D01C647)。

摘　　要：糖尿病视网膜病变(DR)是一种致盲性眼病,已经成为全世界面临的较为严重的公共卫生负担。而DR的发病机理不是完全明确,预防较治疗意义更大,糖尿病患者未发生DR之前运用各种有效方法干预可能对延缓DR发展有积极作用。氧化应激参与DR的发病过程,而维生素C又称抗坏血酸(AA)是临床常用的一种抗氧化剂,能通过减轻抗坏血酸过氧化物酶(ascorbate peroxidase)sch的氧化应激(oxidative stress)而起到抗氧化作用。还有许多重要的生物合成过程中也需要AA参与。在糖尿病患者中,血清AA水平较低。AA补充可能通过其抗氧化作用延缓DR的发展。本文就AA与DR之间的关系及机制作一综述。Diabetic retinopathy(DR)is a blinding eye disease that has become a serious public health burden worldwide.However,the pathogenesis of DR Is not completely clear,and prevention is more important than treatment.Therefore,the use of various effective methods before the onset of DR In diabetic patients may have a positive effect on delaying the development of DR.Oxidative stress is involved in the pathogenesis of DR,and vitamin C,also known as Ascorbic acid(AA),is a commonly used clinical antioxidant.It can play an antioxidant role by alleviating the oxidative stress of ascorbate peroxidase sch.AA is also required to participate in many important biosynthesis processes.Serum AA levels are low in diabetic patients.AA supplementation may delay the development of DR Through its antioxidant effect.This paper reviews the relationship and mechanism between AA and DR.

关 键 词：糖尿病视网膜病变 氧化应激 活性氧 维生素C 

分 类 号：R774.1[医药卫生—眼科] R587.2[医药卫生—临床医学]