纳米技术在眼部疾病中的应用  

Application of Nanotechnology in Eye Diseases

作　　者：李君一 刘科琳 袁福杰 王英[2] Li Junyi;Liu Kelin;Yuan Fujie;Wang Ying(Department of Ophthalmology,Luoyang Third People’s Hospital,Luoyang 471002,China;Department of Ophthalmolog,theSecond Hospital of Jilin University Changchun 130000,China)

机构地区：[1]洛阳市第三人民医院,471002 [2]吉林大学第二医院,130000

出　　处：《临床眼科杂志》2024年第4期373-378,358,共7页Journal of Clinical Ophthalmology

摘　　要：由于眼的独特解剖及生理屏障作用,有效的眼部药物递送存在巨大的挑战,目前传统的非侵入性及侵入性治疗存在生物利用度低、部分伴随着严重的不良反应。纳米眼科学中的纳米技术处于临床应用的早期阶段,纳米级材料在给定的每单位尺寸下,将提供更多的合成反应场所,纳米技术有可能通过克服眼部生理解剖屏障改善药物生物利用度及外科手术干预的失败率,增强现有的诊断筛查工具。本综述重点介绍了纳米技术在眼部疾病诊断及治疗的相关尝试及进展,本文所述的进展可能为新的、高效的眼科纳米药物铺平道路。Due to the unique anatomy and physiological barrier function of the eye,there are huge challenges in effective ocular drug delivery.The current traditional non-invasive and invasive treatments have low bioavailability and some are accompanied by serious adverse reactions.Nanotechnology in nano-ophthalmology is in the early stages of clinical application.Nanoscale materials will provide more sites for synthetic reactions at a given size per unit.Nanotechnology has the potential to improve drug bioavailability by overcoming ocular physiological anatomical barriers.The degree and failure rate of surgical interventions,and enhancing existing diagnostic screening tools.This review focuses on the related attempts and progress of nanotechnology in the diagnosis and treatment of ocular diseases.The progress described in this article may pave the way for new and highly effective ophthalmic nanomedicines.

关 键 词：纳米粒子 脂质体 树枝状大分子 金纳米粒子 

分 类 号：R77[医药卫生—眼科] R318[医药卫生—临床医学]