超声SWE联合BRAF V600E基因突变对甲状腺细针穿刺活检不明确结节的诊断价值  

The diagnostic value of shear wave elastography combined with BRAF V600E gene mutation in unclear nodules of thy⁃roid fine needle biopsy

作　　者：孙泽良 寇光玲 栾艳艳[2] 王玉玲[2] 刘德美[3] 王春光[2] 王映人 SUN Zeliang;KOU Guangling;LUAN Yanyan;WANG Yuling;LIU Demei;WANG Chungaung;WANG Yingren(School of Medical Imaging,Shandong Second Medical University,Weifang 261053,China;Department of Ultrasound,Weifang People's Hospital,Shandong Province,Weifang 261041,China;Department of Pathology,Weifang People's Hospital,Shandong Province,Weifang 261041,China)

机构地区：[1]山东第二医科大学医学影像学院,山东潍坊261053 [2]山东省潍坊市人民医院超声科,山东潍坊261041 [3]山东省潍坊市人民医院病理科,山东潍坊261041

出　　处：《医学影像学杂志》2024年第8期33-36,共4页Journal of Medical Imaging

基　　金：山东省潍坊市卫生健康委员会科研项目(编号:WFWSJK-2023-351)。

摘　　要：目的 探讨剪切波弹性成像(SWE)联合BRAF V600E基因突变检测对甲状腺细针穿刺活检(FNA)意义不明确结节的诊断价值。方法 选取在本院行FNA病理意义不明确的不典型病变或滤泡性病变的患者85例,共98个结节,均接受SWE测量、BRAF V600E基因检测和手术治疗,依据手术病理结果,分析SWE、BRAF V600E基因对该类结节良恶性诊断的应用价值。结果 98个结节中手术后病理诊断良性结节65个,恶性结节33个,SWE、BRAF V600E基因及其联合应用诊断此类结节的敏感度分别为78.9%、78.8%和85.6%,特异度分别为72.7%、93.8%和86.7%,差异有统计学意义(P<0.05)。结论 SWE和BRAF V600E基因联合检测的曲线下面积最大,说明其联合应用比单独使用两种方法更有效。Objective The purpose of this study is to investigate the diagnostic value of shear wave elastography(SWE)com-bined with BRAF V600E gene mutation detection for unclear nodules of thyroid fine needle biopsy.Methods 98 nodules with fine needle biopsy were atypical lesions or follicular lesions in our hospital,all of which received SWE measurement,BRAF V600E gene testing and surgical treatment.According to the surgical pathological results,the application value of SWE and BRAF V600E in the diagnosis of benign and malignant nodules was retrospectively analyzed.Results Of the 98 nodules,the pathological results showed 65 benign nodules and 33 malignant nodules.The sensitivity of SWE,BRAF V600E and the combi-nation of both was 78.9%,78.8%and 85.6%,and the specificity was 72.7%,93.8%and 86.7%,respectively(P<0.05).Con-clusion The area under the curve is largest by SWE and BRAF V600E,indicating that the combination is more effective than the two methods alone.

关 键 词：甲状腺肿瘤 剪切波弹性成像 甲状腺细针穿刺 超声检查 

分 类 号：R736.1[医药卫生—肿瘤] R445.1[医药卫生—临床医学]